Neuropeptides in modulation of Drosophila behavior: how to get a grip on their pleiotropic actions
- Published
- Accepted
- Subject Areas
- Animal Behavior, Neuroscience, Zoology
- Keywords
- Neuropeptides, peptide hormones, neuromodulation, behavior orchestration
- Copyright
- © 2019 Nässel et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2019. Neuropeptides in modulation of Drosophila behavior: how to get a grip on their pleiotropic actions. PeerJ Preprints 7:e27531v1 https://doi.org/10.7287/peerj.preprints.27531v1
Abstract
Neuropeptides constitute a large and diverse class of signaling molecules that are produced by many types of neurons, neurosecretory cells, endocrines and other cells. Many neuropeptides display pleiotropic actions either as neuromodulators, co-transmitters or circulating hormones, while some play these roles concurrently. Here, we highlight pleiotropic functions of neuropeptides and different levels of neuropeptide signaling in the brain, from context-dependent orchestrating signaling by higher order neurons, to local executive modulation in specific circuits. Additionally, orchestrating neurons receive peptidergic signals from neurons conveying organismal internal state cues and relay these to executive circuits. We exemplify these levels of signaling with four neuropeptides, SIFamide, short neuropeptide F, allatostatin-A and leucokinin, each with a specific expression pattern and level of complexity in signaling.
Author Comment
This is a literature review submitted to Current Opinion in Insect Science
Supplemental Information
Supplemental Material Table showing peptides regulating behavior
Multiple neuropeptides are known to regulate behavior in Drosophila (shown with list of acronyms)