Effects of ROS in human adrenocortical carcinoma SW-13 cells
1
Cellevolt, Niigata, Niigata, Japan
2
Office for Equality and Diversity, Niigata University, Niigata, Niigata, Japan
3
Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan
- Published
- Accepted
- Subject Areas
- Cell Biology, Molecular Biology
- Keywords
- Paraquat, SW-13, ROS, adrenocortical carcinoma
- Copyright
- © 2018 Shimada et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Preprints) and either DOI or URL of the article must be cited.
- Cite this article
- 2018. Effects of ROS in human adrenocortical carcinoma SW-13 cells. PeerJ Preprints 6:e27457v1 https://doi.org/10.7287/peerj.preprints.27457v1
Abstract
Paraquat is a highly effective contact herbicide, an inducer of reactive oxygen species (ROS), which generate oxidative stress in cells. Reactive oxygen species has been known to function as an important messenger in cell differentiation. In this study, we investigated the effect of paraquat on cell differentiation using human adenocortical carcinoma (ACC) SW-13 cells. Paraquat, an inducer of intracellular reactive oxygen species, induced the differentiation of SW-13 cells into neural-like cells in the presence of neurofilament. Moreover, paraquat exposure promoted SW-13 cell proliferation and increased intracellular Ca2+ concentration.
Author Comment
This is a preprint submission to PeerJ Preprints.