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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Koen Van Den Berge conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Katharina Hembach conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Charlotte Soneson conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Simone Tiberi conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Lieven Clement conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Michael I Love conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Rob Patro conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Mark Robinson conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Data Deposition

The following information was supplied regarding data availability:

All data is already publicly available.

The research in this article did not generate any data or code (all data is already publicly available).

Funding

This work was supported by Research Foundation - Flanders (FWO; 1S 418 16N), the National Human Genome Research Institute [R01 HG009125], the National Cancer Institute [P01 CA142538], the National Institute of Environmental Health Sciences [P30 ES010126], US National Natural Science Foundation (BIO-1564917, CCF-1750472, CNS-1763680), ,the US National Institutes of Health (R01HG009937), and the Swiss National Science Foundation (310030_175841, CRSII5_177208). In addition, this project has been made possible in part (grant numbers 2018-182752, 2018-182828) from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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