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Additional Information

Competing Interests

Conflicts of interest: LP reports personal fees from Otsuka Canada, SPMM Course Limited, UK, Canadian Psychiatric Association; book royalties from Oxford University Press; investigator-initiated educational grants from Janssen Canada, Otsuka Canada; travel support from Boehringer Ingelheim and Magstim Limited outside the submitted work. In the last 3 years, LP and/or his spouse have held shares in Shire Pharmaceuticals and Glaxo Smith Kline in their pension funds for values less than US$10,000.

Author Contributions

Lena Palaniyappan conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, prepared figures and/or tables, authored or reviewed drafts of the paper, approved the final draft.

Data Deposition

The following information was supplied regarding data availability:

this is a review


Funding: L Palaniyappan’s work is supported by the Canadian Institute of Health Research (Foundation Grant 375104), Bucke Family Fund and the Academic Medical Organization of South Western Ontario. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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