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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Daniel A Moreira conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables.

Raquel Soares contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Richard H Valente contributed reagents/materials/analysis tools, reviewed drafts of the paper.

Maria João A Bebianno reviewed drafts of the paper.

Mauro de Freitas Rebelo conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Comissão de Ética no Uso de Animais do Centro de Ciências da Saúde http://www.ccs.ufrj.br/pt/sobre-o-ccs/coordenacoes/cambe/ceua

Project number: IBCCF177

Data Deposition

The following information was supplied regarding data availability:

The raw data has been supplied as a supplementary file.

Funding

This work was supported by grant E-26/111.540/2008 from the Rio de Janeiro State Research Council - FAPERJ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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