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Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Rafaela C Sartore conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Simone C Cardoso conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Yuri V Lages performed the experiments.

Julia M Paraguassu performed the experiments.

Rodrigo F Madeiro da Costa conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables.

Marilia ZP Guimarães conceived and designed the experiments, analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Carlos A Pérez conceived and designed the experiments, contributed reagents/materials/analysis tools.

Stevens K Rehen conceived and designed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Comitê de Ética em Pesquisa do Hospital das Clínicas da Faculdade de Medicina (CAPPesq, HCPA) (IRB00000921) and Comitê de Ética em Pesquisa do Hospital Copa D'Or (CEPCOPADOR) (727.269)

Funding

This work was funded by BNDES, FAPERJ, FINEP, CNPq and LNLS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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