Vaccine coverage and the cost effectiveness of dengue vaccine in South East Asia
- Published
- Accepted
- Subject Areas
- Computational Biology, Mathematical Biology, Infectious Diseases
- Keywords
- Dengue, Cost effective, Mathematical Model, Vaccination
- Copyright
- © 2016 Polwiang
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2016. Vaccine coverage and the cost effectiveness of dengue vaccine in South East Asia. PeerJ PrePrints 4:e1694v1 https://doi.org/10.7287/peerj.preprints.1694v1
Abstract
Background: Dengue is one of the most important vector-borne diseases, nearly 400000 reported cases in South East Asia and more than 2000 fatalities annually. The first of dengue vaccine called Dengvaxia by the French company, Sanofi Pasteur, was recently approved in Mexico, Brazil and the Philippines to be used for persons who are 9-45 years of age. Objective: The objective of this study was to estimate the effective of a vaccine to dengue transmission and the cost-effectiveness of the vaccine in South East Asia (SEA). Methods: The simulation and analysis was carried out using a mathematical model for dengue transmission. The vaccine was given to a certain part of population in the community and the number of dengue infections and incidences was then calculated. The cost effective price of the vaccine was measured as disability adjusted life years (DALYs) averted, and the incremental cost-effectiveness ratio (ICER) of the vaccination was expressed in 2015 US dollars per DALY averted for the countries in SEA. Results: The herd immunity was observed in the model simulation. The number of dengue incidences was declined with increased vaccine coverage in the community. If a vaccination program would be implemented the highly cost effective of vaccine per person should be 25-28 US dollars in SEA country on the average. Conclusions: Our results describe effects of the dengue vaccination to infections and incidences. The price of the vaccine has been calculated and and it is different in each SEA country due to several factors such as the number of incidences, the GDP per capita, the hospital costs and the DALYs.
Author Comment
This is a submission to PeerJ for review. Comments are welcome.