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Supplemental Information

Additional Information

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Ryuta Kinugasa conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Yoshiyuki Usami wrote the paper, reviewed drafts of the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The subject was fully informed about the experimental protocol and the purpose of the study and provided written informed consent to participate in the investigation. This study was approved by the Kanagawa University Ethics Review Committee for Research Involving Human Participants (2012-1).

Data Deposition

The following information was supplied regarding data availability:


This study was supported by Research Collaboration Grant, Kanagawa University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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