Transgenerational effects enhance specific immune response in a wild passerine
- Published
- Accepted
- Subject Areas
- Evolutionary Studies, Virology, Zoology, Immunology, Infectious Diseases
- Keywords
- UO/CISC/PA), Research Unit of Biodiversity. (UMIB, Antibodies, Immune priming, Passer domesticus., Newcastle disease Virus, Oxidative stress
- Copyright
- © 2015 Broggi et al.
- Licence
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ PrePrints) and either DOI or URL of the article must be cited.
- Cite this article
- 2015. Transgenerational effects enhance specific immune response in a wild passerine. PeerJ PrePrints 3:e1380v1 https://doi.org/10.7287/peerj.preprints.1380v1
Abstract
Vertebrate mothers transfer diverse compounds to developing embryos that can affect their development and final phenotype (i.e. maternal effects). However, the way such effects modulate offspring phenotype, in particular their immunity remains unclear. To test the impact of maternal effects on offspring development we treated with Newcastle disease virus (NDV) vaccine wild breeding house sparrow (Passer domesticus) females in Sevilla, SE Spain. Female parents were vaccinated when caring first broods, and their offspring from their following brood were evaluated for their immune response to the same vaccine and to the PHA inflammatory test. Vaccinated chicks from vaccinated mothers developed a stronger specific response that was related to maternal NDV antibody concentration. Chick’s carotenoid concentration and total antioxidant capacity in blood were negatively related to NDV antibody concentration, whereas no relation with PHA response was found. Specific NDV antibodies could not be detected on 10 day old control chicks from vaccinated mothers, implying that maternally transmitted antibodies promote offspring specific immunity through a priming effect, while other immunity components remain unaffected. Maternally transmitted antibodies are short-lived, depend on maternal circulation levels and may be adaptive when chicks are frequently exposed to the same pathogens as their mothers.
Author Comment
This is a submission to PeerJ for peer-review
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