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This paper explores a possible underlying tenet of classical information-feed pathways (feedback and feedforward) as seen in metabolism and signaling in biological systems. We intend to determine whether information-feed pathways derive from spatial and temporal overlap of event occurrences involving connection points of the information-feed loop. We shall revisit three known and established biological phenomena involving information-feed, in an attempt to deduce the principles governing such phenomena. We propose that such principles involve anticipatory associations.