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Additional Information

Competing Interests

We declare that there are no competing interests.

Author Contributions

Sven Rahmann conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper.

Jasmin Beygo performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper.

Deniz Kanber performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper.

Marcel Martin contributed reagents/materials/analysis tools, wrote the paper, invented the flowgram-to-string alignment algorithm..

Bernhard Horsthemke conceived and designed the experiments, performed the experiments, wrote the paper.

Karin Buiting conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Human blood samples were obtained after written informed consent. Control blood samples from blood donors were anonymised. The study was approved by the ethics committee of the University Duisburg-Essen (08-3858).

Grant Disclosures

The following grant information was disclosed by the authors:

Bundesministerium für Bildung und Forschung (BMBF) 01GM1114A and 01KU1216E; Mercator Research Center Ruhr (MERCUR) Pe-2013-0012

Data Deposition

The following information was supplied regarding the deposition of related data:

https://bitbucket.org/svenrahmann/amplikyzer/downloads

Funding

Part of this work was supported by the German Bundesministerium für Bildung und Forschung (BMBF) as grant numbers 01GM1114A and 01KU1216E. SR acknowledges support from the Mercator Foundation within project MERCUR Pe-2013-0012 (UAMR Professorship "Computational Biology"). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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