Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss

View article
PeerJ

Main article text

 

Introduction

Materials and Methods

The population and traits

Genotyping and molecular markers

Preliminary analyses

QTL mapping

Results

Energy balance traits

Whole body traits

Body composition traits

Bone traits

Discussion

Energy consumption and expenditure QTLs

Body weight QTLs

Adiposity QTLs

Organ weight QTLs

Bone QTLs

Summary

Supplemental Information

SNP markers used with their chromosome and coordinates

DOI: 10.7717/peerj.392/supp-1

MLI/MLI, MHI/MHI, and MLI/MHI genotype frequencies at each marker on all chromosomes

Mb = megabases.

DOI: 10.7717/peerj.392/supp-2

Example of QTLRel code

DOI: 10.7717/peerj.392/supp-3

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Larry J. Leamy analyzed the data, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper.

Kari Elo and Merlyn K. Nielsen conceived and designed the experiments, performed the experiments, reviewed drafts of the paper.

Stephanie R. Thorn performed the experiments, reviewed drafts of the paper.

William Valdar analyzed the data, reviewed drafts of the paper.

Daniel Pomp conceived and designed the experiments, performed the experiments, wrote the paper, reviewed drafts of the paper.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

University of Nebraska-Lincoln Animal Care and Use Committee: Protocol 2-2-010.

Funding

We received support from NIH grants GM060029, DK076050 and DK056350. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

3 Citations 2,403 Views 593 Downloads