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Bronze Contributor

Fanglin Guan

PeerJ Editor

Summary

Prof. Fanglin Guan is Dean at Xi'an Jiaotong University. He is engaged in the integrated biological research of complex diseases, including tumor microenvironment and novel immunotherapeutic modalities, and research on the mechanisms and medical applications related to tumor cell vaccines, especially for the exploration of the mechanism of determining the biomarkers of complex diseases.

Biochemistry Bioinformatics Biomolecules Biotechnology Cell Biology Computational Biology COVID-19 Data Mining & Machine Learning Environmental Health Epidemiology Genetics Genomics Immunology Infectious Diseases Medical Genetics Mental Health Molecular Biology Neuroscience Oncology Ophthalmology Orthopedics Pharmacology Psychiatry & Psychology Public Health Translational Medicine

Section Editor

Bioinformatics and Genomics

Editorial Board Member

PeerJ - the Journal of Life & Environmental Sciences

Work details

Dean

Xi'an Jiaotong University

Bio-evidence Sciences Academy

Engaged in the integrated biological research of complex diseases, including tumor microenvironment and novel immunotherapeutic modalities, and research on the mechanisms and medical applications related to tumor cell vaccines, especially for the exploration of the mechanism of determining the biomarkers of complex diseases.

PeerJ Contributions

Edited 55

Academic Editor on

August 18, 2025

Relationship between heart rate variability parameters and inflammatory activity in patients with Crohn’s disease: a retrospective study

Beibei Wang, Shanying Liao, Linlin Huang, Zhongwen Zheng, Can Cui

https://doi.org/10.7717/peerj.19893 PubMed 40852384

August 11, 2025

Development of a relapse-related RiskScore model to predict the drug sensitivity and prognosis for patients with ovarian cancer

Zhixin Jin, Xuegu Wang, Xiang Li, Shasha Yang, Biao Ding, Jiaojiao Fei, Xiaojing Wang, Chengli Dou

https://doi.org/10.7717/peerj.19764 PubMed 40821986

May 22, 2025

Sialyltransferase-related genes as predictive factors for therapeutic response and prognosis in cervical cancer

Jia Shao, Can Zhang, Yaonan Tang, Aiqin He, Xiangyan Cheng

https://doi.org/10.7717/peerj.19422 PubMed 40416607

May 20, 2025

Bulk and single-cell RNA sequencing identify prognostic signatures related to FGFBP2⁺ NK cell in hepatocellular carcinoma

Yinbing Wu, Huanjun Peng, Guangkang Chen, Yinuo Tu, Xinpei Yu

https://doi.org/10.7717/peerj.19337 PubMed 40416605

May 13, 2025

Effects of perioperative massive transfusion on postoperative outcomes of children undergoing brain tumor removal: a retrospective cohort study

Yingyi Xu, Na Zhang, Xinxu Ou, Yuyin Ye, Jianhua Liu, Siyi Zhang, Xinke Xu, Yu Gao, Wenchu Chen, Xingrong Song

https://doi.org/10.7717/peerj.19350 PubMed 40386226

May 8, 2025

Development of an immune-related gene signature applying Ridge method for improving immunotherapy responses and clinical outcomes in lung adenocarcinoma

Zhen Chen, Yongjun Zhang

https://doi.org/10.7717/peerj.19121 PubMed 40352269

April 30, 2025

Metabolomics and proteomics analyses reveal the role of the glycerophospholipid metabolism pathway in unexplained recurrent spontaneous abortion

Yihong Chen, Xiumei Zhao, Bei Gan, Leiyi Jin, Juanbing Wei, Jianying Yan

https://doi.org/10.7717/peerj.19317 PubMed 40321821

April 16, 2025

Biomarkers associated with cell-in-cell structure in kidney renal clear cell carcinoma based on transcriptome sequencing

Zehua Wang, Zhongxiao Zhang

https://doi.org/10.7717/peerj.19246 PubMed 40256740

April 15, 2025

Multiple instance learning-based prediction of programmed death-ligand 1 (PD-L1) expression from hematoxylin and eosin (H&E)-stained histopathological images in breast cancer

Zhen Da, Heng Yang, Bianba Zhaxi, Kaixiang Sun, Guohui Bai, Chao Wang, Feiyan Wang, Weijun Pan, Rui Du

https://doi.org/10.7717/peerj.19201 PubMed 40256728

April 8, 2025

DLEU2 facilitates bladder cancer progression through miR-103a-2-5p/SOS1 axis

Yinlong Liu, Jian Hu, Baochun Liao, Zhijian Zhu, Yong Liu, Qinghua Pan

https://doi.org/10.7717/peerj.18995 PubMed 40226549

April 7, 2025

Association between receiving the Aksi Bergizi Social Behavioral Change Communication (SBCC) intervention and hygiene behaviors among secondary school students in Padang, Indonesia

Ricvan Dana Nindrea, Wit Wichaidit

https://doi.org/10.7717/peerj.19256 PubMed 40212367

March 31, 2025

Computed tomography-based radiomic features combined with clinical parameters for predicting post-infectious bronchiolitis obliterans in children with adenovirus pneumonia: a retrospective study

Li Zhang, Ling He, Guangli Zhang, Xiaoyin Tian, Haoru Wang, Fang Wang, Xin Chen, Yinglan Zheng, Man Li, Yang Li, Zhengxiu Luo

https://doi.org/10.7717/peerj.19145 PubMed 40183053

February 13, 2025

Association between visceral fat and bone mineral density in perimenopausal women

Xu Tang, Ling Tang, Xiaolin Li, Jiejing Cao, Huanhuan Wang, Shujiao Liu, Yufang Yi, Zhiyong Zhang

https://doi.org/10.7717/peerj.18957 PubMed 39959823

February 13, 2025

Integrated genomic analysis of the stemness index signature of mRNA expression predicts lung adenocarcinoma prognosis and immune landscape

Xingzhao Lu, Wei Du, Jianping Zhou, Weiyang Li, Zhimin Fu, Zhibin Ye, Guobiao Chen, Xian Huang, Yuliang Guo, Jingsheng Liao

https://doi.org/10.7717/peerj.18945 PubMed 39959839

February 10, 2025

A gene signature related to programmed cell death to predict immunotherapy response and prognosis in colon adenocarcinoma

Lei Zheng, Jia Lu, Dalu Kong, Yang Zhan

https://doi.org/10.7717/peerj.18895 PubMed 39950044

February 7, 2025

Assessing the quality of life among African medical and health science students using the WHOQOL-BREF tool

Fatima Alzahra Galgam, Adil Abdalla, Mahmoud Shahin, Magda Yousif, Nahla Abdulrahman, Fatmah Alamoudi, Mehrunnisha Ahmad, Amira Yahia, Mohammad Sidiq, Aksh Chahal, Fuzail Ahmad, Mohammad Abu Shaphe, Gopal Nambi, Moattar Raza Rizvi, Faizan Kashoo

https://doi.org/10.7717/peerj.18809 PubMed 39931073

January 31, 2025

Fructose 1,6-bisphosphatase 1 is a potential biomarker affecting the malignant phenotype and aerobic glycolysis in glioblastoma

Weihong Lu, Guozheng Huang, Yihan Yu, Xia Zhai, Xiangfeng Zhou

https://doi.org/10.7717/peerj.18926 PubMed 39902328

January 8, 2025

Clinical characteristics of pathogens in children with community-acquired pneumonia were analyzed via targeted next-generation sequencing detection

Junhua Zhao, Mingfeng Xu, Zheng Tian, Yu Wang

https://doi.org/10.7717/peerj.18810 PubMed 39802179

December 24, 2024

Regulation of lymphoma in vitro by CLP36 through the PI3K/AKT/CREB signaling pathway

Chao Lv, Guannan Chen, Shuang Lv

https://doi.org/10.7717/peerj.18693 PubMed 39735560

December 23, 2024

Implications of the SNHG10/miR-665/RASSF5/NF-κB pathway in dihydromyricetin-mediated ischemic stroke protection

Qi Zeng, Yan Xiao, Xueliang Zeng, Hai Xiao

https://doi.org/10.7717/peerj.18754 PubMed 39726744

December 20, 2024

Construction and clinical application of a risk model based on N6-methyladenosine regulators for colorectal cancer

Hanhan Zhu, Yu Yang, Zhenfeng Zhou

https://doi.org/10.7717/peerj.18719 PubMed 39717046

November 27, 2024

The effects of plasma from patients with active thyroid-associated orbitopathy on the survival and inflammation of melanoma-associated fibroblasts

Huifang Chen, Shiyuan Chen, Zhenfeng Liu

https://doi.org/10.7717/peerj.18612 PubMed 39619202

November 21, 2024

Development and validation of a simple clinical nomogram for predicting infectious diseases in pediatric kidney transplantation recipients: a retrospective study

Li Li, Meng Fu, Changshan Wang, Yuxin Pei, Lizhi Chen, Liping Rong, Yuanyuan Xu, Zhilang Lin, Yuanquan Qiu, Xiaoyun Jiang, Mengjie Jiang

https://doi.org/10.7717/peerj.18454 PubMed 39583098

November 21, 2024

Single-cell data revealed the function of natural killer cells and macrophage cells in chemotherapy tolerance in acute myeloid leukemia

Jing Gao, Xueqian Yan, Dan Fan, Yuanchun Li

https://doi.org/10.7717/peerj.18521 PubMed 39583114

November 15, 2024

Cirsilineol improves anesthesia/surgery-induced postoperative cognitive dysfunction through attenuating oxidative stress and modulating microglia M1/M2 polarization

Junli Du, Chao Chen, Jie Chen

https://doi.org/10.7717/peerj.18507 PubMed 39559329

November 14, 2024

Comprehensive analysis of transcriptomics and radiomics revealed the potential of TEDC2 as a diagnostic marker for lung adenocarcinoma

Qian Huang, Peng Zhang, Zhixu Guo, Min Li, Chao Tao, Zongyang Yu

https://doi.org/10.7717/peerj.18310 PubMed 39553728

November 5, 2024

MiR-301b-3p promotes breast cancer development through inhibiting the expression of transforming growth factor-beta receptor 2

Jian Lou, Xueni Liu, Yanru Xie, Minhua Wu, Weibo Mao, Xiaozhen Ying

https://doi.org/10.7717/peerj.18324 PubMed 39525474

November 1, 2024

Potential molecular mechanisms of ETV6-RUNX1-positive B progenitor cell cluster in acute lymphoblastic leukemia revealed by single-cell RNA sequencing

Ning Qu, Yue Wan, Xin Sui, Tianyi Sui, Yang Yang

https://doi.org/10.7717/peerj.18445 PubMed 39498293

October 28, 2024

Exploring tumor endothelial cells heterogeneity in hepatocellular carcinoma: insights from single-cell sequencing and pseudotime analysis

Jiachun Sun, Shujun Zhang, Yafeng Liu, Kaijie Liu, Xinyu Gu

https://doi.org/10.7717/peerj.18362 PubMed 39484208

October 28, 2024

The impact of maternal serum biomarkers on maternal and neonatal outcomes in twin pregnancies: a retrospective cohort study conducted at a tertiary hospital

Hanglin Wu, Liming Yu, Zhen Xie, Hongxia Cai, Caihe Wen

https://doi.org/10.7717/peerj.18415 PubMed 39484218

October 21, 2024

Single-cell RNA-seq analysis revealed the stemness of a specific cluster of B cells in acute lymphoblastic leukemia progression

Guifang Wang, Ensheng Zhang, An Chen, Dachuan Meng

https://doi.org/10.7717/peerj.18296 PubMed 39465162

October 21, 2024

Indigo alleviates psoriasis through the AhR/NF-κB signaling pathway: an in vitro and in vivo study

Yu Lin, Lihong Yang, Dongxiang Wang, Haiqing Lei, Yuelin Zhang, Wen Sun, Jing Liu

https://doi.org/10.7717/peerj.18326 PubMed 39465158

October 11, 2024

The characteristics and associations between trait and state time perspective in adolescents with depression: a questionnaire and sandplay study

Hanlin Ren, Qing Zhang, Donghuan Rong, Yating Zhang, Yanzhen Ren, Xiaobao Li

https://doi.org/10.7717/peerj.18257 PubMed 39403191

October 9, 2024

Pdk3’s role in RANKL-induced osteoclast differentiation: insights from a bone marrow macrophage model

Nan Zhang, Lingting Wang, Xuxin Ye

https://doi.org/10.7717/peerj.18222 PubMed 39399421

September 25, 2024

Identification of a novel immune infiltration-related gene signature, MCEMP1, for coronary artery disease

Wei Ye, Bo Shen, Qizhu Tang, Chengzhi Fang, Lei Wang, Lili Xie, Qi He

https://doi.org/10.7717/peerj.18135 PubMed 39346078

September 6, 2024

Polycystic ovarian syndrome (PCOS) and recurrent spontaneous abortion (RSA) are associated with the PI3K-AKT pathway activation

Wenjing Lin, Yuting Wang, Lei Zheng

https://doi.org/10.7717/peerj.17950 PubMed 39253602

August 21, 2024

Comparison of visual quality after wavefront-guided LASIK in patients with different levels of preoperative total ocular higher-order aberrations: a retrospective study

Yu Zhang, Yangrui Du, Ming He, Youdan Zhang, Zhiyu Du

https://doi.org/10.7717/peerj.17940 PubMed 39184392

August 5, 2024

Sijie Feng, Linwei Ning, Huizhen Zhang, Zhenhui Wang, Yunkun Lu

https://doi.org/10.7717/peerj.17861 PubMed 39119106

July 10, 2024

Construction and validation of a prognostic model for gastric cancer patients with tumor deposits

Ran Xu, Yisheng Zhang, Zhengguang Wang, Ke Chen, Jun Zhao

https://doi.org/10.7717/peerj.17751 PubMed 39006037

June 24, 2024

Integrated bulk and single-cell RNA sequencing identifies an aneuploidy-based gene signature to predict sensitivity of lung adenocarcinoma to traditional chemotherapy drugs and patients’ prognosis

Xiaobin Wang, Jiakuan Chen, Chaofan Li, Yufei Liu, Shiqun Chen, Feng Lv, Ke Lan, Wei He, Hongsheng Zhu, Liang Xu, Kaiyuan Ma, Haihua Guo

https://doi.org/10.7717/peerj.17545 PubMed 38938612

May 15, 2024

Effects of extreme meteorological factors and high air pollutant concentrations on the incidence of hand, foot and mouth disease in Jining, China

Haoyue Cao, Rongrong Xu, Yongmei Liang, Qinglin Li, Wenguo Jiang, Yudi Jin, Wenjun Wang, Juxiang Yuan

https://doi.org/10.7717/peerj.17163 PubMed 38766480

April 9, 2024

The role of echinacoside-based cross-linker nanoparticles in the treatment of osteoporosis

Dandan Hu, Chunan Cheng, Zhen Bian, Yubo Xu

https://doi.org/10.7717/peerj.17229 PubMed 38618561

March 26, 2024

The feasibility of the posterior tibial nerve-flexor hallucis brevis pathway applied in neuromuscular monitoring: a multicentric, controlled, and prospective clinical trial

Weiqiang Chen, Zhijian Chen, Fang Cheng, Zhuodan Wang, Juan Li, Shangrong Li, Hanbin Xie

https://doi.org/10.7717/peerj.17154 PubMed 38560472

March 22, 2024

Comprehensive analysis of peroxisome proliferator-activated receptors to predict the drug resistance, immune microenvironment, and prognosis in stomach adenocarcinomas

Qing Jia, Baozhen Li, Xiulian Wang, Yongfen Ma, Gaozhong Li

https://doi.org/10.7717/peerj.17082 PubMed 38529307

February 29, 2024

Research and experimental verification on the mechanisms of cellular senescence in triple-negative breast cancer

Tengfei Cao, Mengjie Huang, Xinyue Huang, Tian Tang

https://doi.org/10.7717/peerj.16935 PubMed 38435998

January 31, 2024

Using molecular characteristics to distinguish multiple primary lung cancers and intrapulmonary metastases

Zhenhua Li, Huilai Lv, Fan Zhang, Ziming Zhu, Qiang Guo, Mingbo Wang, Chao Huang, Lijie Guo, Fanfei Meng, Ziqiang Tian

https://doi.org/10.7717/peerj.16808 PubMed 38313018

January 22, 2024

Single-cell data revealed CD14-type and FCGR3A-type macrophages and relevant prognostic factors for predicting immunotherapy and prognosis in stomach adenocarcinoma

Mengling Li, Ming Lu, Jun Li, Qingqing Gui, Yibin Xia, Chao Lu, Hongchun Shu

https://doi.org/10.7717/peerj.16776 PubMed 38274323

December 18, 2023

LINC00969 inhibits proliferation with metastasis of breast cancer by regulating phosphorylation of PI3K/AKT and ILP2 expression through HOXD8

Xiaoyun Wen, Ya Hou, Liang Zhou, Xiansong Fang

https://doi.org/10.7717/peerj.16679 PubMed 38130932

December 7, 2023

Inhibition of hepatocellular carcinoma growth via modulation of the miR-221/SOX11 axis by curcumin and berberine

Sheng Li, Xiaoliang Cai, Liang Chen, Manbian Lin, Ziqi Zhu, Huihuang Xiao, Pingping Nie, Quanwen Chen, Xiaoyu Yang

https://doi.org/10.7717/peerj.16593 PubMed 38084140

November 27, 2023

Sirtuin 1 alleviates alcoholic liver disease by inhibiting HMGB1 acetylation and translocation

Juan Fu, Wei Deng, Jun Ge, Shengqi Fu, Panpan Li, Huazhi Wu, Jiao Wang, Yi Gao, Hui Gao, Tao Wu

https://doi.org/10.7717/peerj.16480 PubMed 38034869

November 17, 2023

Chicago sky blue gel for better visualization of Demodex in patients with Demodex blepharitis

Lunla Udomwech, Weeratian Tawanwongsri, Auemphon Mordmuang

https://doi.org/10.7717/peerj.16378 PubMed 38025681

November 14, 2023

Immune activity score to assess the prognosis, immunotherapy and chemotherapy response in gastric cancer and experimental validation

Xuan Wu, Fengrui Zhou, Boran Cheng, Gangling Tong, Minhua Chen, Lirui He, Zhu Li, Shaokang Yu, Shubin Wang, Liping Lin

https://doi.org/10.7717/peerj.16317 PubMed 38025711

November 14, 2023

Temporal bright light at low frequency retards lens-induced myopia in guinea pigs

Baodi Deng, Wentao Li, Ziping Chen, Junwen Zeng, Feng Zhao

https://doi.org/10.7717/peerj.16425 PubMed 38025747

September 26, 2023

Friend leukemia integration 1 overexpression decreases endometrial receptivity and induces embryo implantation failure by promoting PART1 transcription in the endometrial epithelial cells

Yile Zhang, Beining Yin, Sichen Li, Yueyue Cui, Jianrong Liu

https://doi.org/10.7717/peerj.16105 PubMed 37780395

September 11, 2023

Pramipexole has a neuroprotective effect in spinal cord injury and upregulates D2 receptor expression in the injured spinal cord tissue in rats

Xuchen Liu, Chengqiang Wang, Qingshan Peng, Birong Peng, Lixin Zhu

https://doi.org/10.7717/peerj.16039 PubMed 37719118