Parvovirus B19 DNA and antibodies in Chinese plasma donors, plasma pools and plasma derivatives

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Microbiology

Main article text

 

Introduction

Materials & Methods

Sample collection

B19V DNA quantitation

Phylogenetic analysis

B19V serologic assays

Descriptive statistics

Results

Prevalence of B19V DNA and antibodies in plasma donors

B19V DNA and antibodies in plasma pools for fractionation

B19V DNA and antibodies in plasma derivatives

Phylogenetic relationships among different B19V isolates

Discussion

Conclusion

Supplemental Information

B19V sequences used to reconstruct the phylogenetic tree

DOI: 10.7717/peerj.15698/supp-1

Sequence submission

DOI: 10.7717/peerj.15698/supp-2

Sequence acession number in GenBank

DOI: 10.7717/peerj.15698/supp-3

Additional Information and Declarations

Competing Interests

Xiangzhong Ye, Shangzhi Ji and Jinle Han are employed by Beijing Wantai Biological Pharmacy. Kuilin Lu and Xuexin He are employed by Chengdu Rongsheng Pharmaceutical Co., Ltd. Jiajin Fan and Dawei Cao are employed by Shandong Taibang Biological Products Co., Ltd. Yu Zhang and Yongsheng Yin are employed by Hualan Biological Products Co., Ltd. Yunhua Chen and Xuemei Zhao are employed by Guizhou Taibang Biological Products Co., Ltd.

Author Contributions

Pan Sun performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Peng Jiang analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Qing Liu analyzed the data, prepared figures and/or tables, and approved the final draft.

Rong Zhang analyzed the data, prepared figures and/or tables, and approved the final draft.

Zongkui Wang conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Haijun Cao conceived and designed the experiments, prepared figures and/or tables, and approved the final draft.

Xiangzhong Ye performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Shangzhi Ji performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Jinle Han performed the experiments, prepared figures and/or tables, and approved the final draft.

Kuilin Lu performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Xuexin He performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Jiajin Fan performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Dawei Cao performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Yu Zhang performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Yongsheng Yin performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Yunhua Chen performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Xuemei Zhao performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Shengliang Ye analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Na Su performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Xi Du performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Li Ma conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Changqing Li conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The Institutional Ethics Review Committee of Institute of Blood Transfusion provided approval to carry out this study (NO: 202029).

Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The Institutional Ethics Review Committee of Institute of Blood Transfusion approved the study (202029).

Data Availability

The following information was supplied regarding data availability:

Data is available at NCBI Genbank: OP954001, OP954002, OP954003, OP954004, OP954005, OP954006, OP954007, OP954008, OP954009, OP954010, OP954011, OP954012, OP954013, OP954014, OP954015, OP954016, OP954017.

Funding

This study was funded by the Drug Quality Standard Improvement Project from Chinese Pharmacopoeia Commission (2019S01, 2020S04), the Medical Research Program Project from Sichuan Province (S21072), and the CAMS Innovation Fund for Medical Sciences (2021-1-I2M-060). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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