Comparison of the clinical value of MRI and plasma markers for cognitive impairment in patients aged ≥75 years: a retrospective study

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Brain, Cognition and Mental Health

Main article text

 

Introduction

Materials and Methods

Patient selection

Data collection

Statistical analysis

Results

Demographic characteristics of all enrolled patients

Comparison of neuroimaging markers between the NCI and CI groups

Comparison of neuroimaging markers between NCI and CI in the A β- and tau- subgroups

Comparison of neuroimaging markers between NCI and CI in the A β-/tau- subgroup

Discussion

Conclusions

Supplemental Information

Supplementary Tables.

DOI: 10.7717/peerj.15581/supp-2

Representations of grades 0, 1, 2, and 3 for DWMH and PVWMH.

DOI: 10.7717/peerj.15581/supp-3

To investigate the clinical application value of plasma amyloid Aβ1-42 (Aβ42), phosphorylated tau 181 (p-tau181) and conventional MRI markers for cognitive impairment (CI) in patients aged ≥75 years, we conducted a retrospective study.

Patients with a clinical diagnosis of CI (n = 54) (yellow) and without CI (n = 130) (blue) were enrolled, clinical variables including plasma indicators (Aβ42 and p-tau181) and conventional structural MRI parameters were collected and analyzed. We found that the CI group (yellow) had higher WMH load, smaller LVBI value, and more severe cortical atrophy compared to the non-CI (NCI) group (blue), while plasma Aβ42 and p-tau181 showed no significant difference between the two groups. The combined model including PVWMH, LVBI, and cortical atrophy to detect CI and NCI showed an area under the ROC curve is 0.782.

DOI: 10.7717/peerj.15581/supp-4

Additional Information and Declarations

Competing Interests

Yaqiong Ge is employed by GE Healthcare. The authors declare that they have no competing interests.

Author Contributions

Wei Wang conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Lin Shi performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.

Hong Ma performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Shiguang Zhu performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Yaqiong Ge performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Kai Xu conceived and designed the experiments, performed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

This retrospective analysis was approved by the ethics committee of the Affiliated Hospital of Xuzhou Medical University (XYFY2022-KL331-01). The requirement for informed consent was waived by the committee.

Data Availability

The following information was supplied regarding data availability:

The raw data are available in the Supplemental Files.

Funding

This study was funded by the National Natural Science Foundation of China (Grant No. 81771904). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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