Effects of high-risk human papillomavirus infection on P53, pRb, and survivin in lung adenocarcinoma—a retrospective study

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Biochemistry, Biophysics and Molecular Biology

Main article text

 

Introduction

Methods

Subjects

Data collection

Detection of HPV infection by flow fluorescence-liquid chip technology

Detection of P53, pRb, and survivin expression in tissues by immunohistochemical staining method

Interpretation criteria of immunohistochemical staining results

Experimental grouping

Statistical analysis

Results

Comparison of HR-HPV infection rate between LUAD group and cancer-adjacent group

Correlation analysis between HR-HPV infection and clinicopathological characteristics of LUAD

Expression of P53, pRb, and survivin in the LUAD group and cancer-adjacent group

Correlation between HR-HPV infection and expression of P53, pRb, and survivin in LUAD

Discussion

Supplemental Information

Additional Information and Declarations

Competing Interests

The authors declare that there are no competing interests.

Author Contributions

Wenwen Sun performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Hui Yang performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Lu Cao performed the experiments, prepared figures and/or tables, and approved the final draft.

Ruochen Wu performed the experiments, prepared figures and/or tables, and approved the final draft.

Baoqi Ding performed the experiments, prepared figures and/or tables, and approved the final draft.

Xiaocui Liu performed the experiments, prepared figures and/or tables, and approved the final draft.

Xinli Wang conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Qiang Zhang conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

The ethics committee of Second Affiliated Hospital of Shandong First Medical University.

Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Ethics committee of The Second Affiliated Hospital of Shandong First Medical University.

Data Deposition

The following information was supplied regarding data availability:

The raw measurements are available in the Supplemental File.

Funding

This work was supported by the Tai’an Science and Technology Innovation Development Project (No. 2021NS231). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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