Terrien, a metabolite made by Aspergillus terreus, has activity against Cryptococcus neoformans

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Microbiology

Main article text

 

Introduction

Materials and Methods

General experimental procedures

Fungal material

Zone of inhibition assays

Fermentation, extraction, and isolation

Terrein (1)

Aspulvinone E (2)

Aspulvinone G (3)

Terretonin (4)

Terretonin A (5)

Asperteretal B (6)

Flavipesolide C (7)

Butyrolactone II (8)

Butyrolactone I (9)

Testing extracts for antimicrobial activity

Testing pure compounds for antimicrobial activity

Statistical analysis

Results

Discussion

Conclusions

Additional Information and Declarations

Competing Interests

Siouxsie Wiles is an Academic Editor for PeerJ.

Author Contributions

Melissa Cadelis conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Alex Grey performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Shara van de Pas performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Soeren Geese performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Bevan S. Weir conceived and designed the experiments, authored or reviewed drafts of the article, and approved the final draft.

Brent Copp conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.

Siouxsie Wiles conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.

Data Availability

The following information was supplied regarding data availability:

The data is available at Figshare:

Wiles, Siouxsie; Geese, Soeren (2022): The activity of Aspergillus terreus ICMP 477 against antibiotic-sensitive and resistant strains of E. coli, K. pneumoniae, and S. aureus by zone of inhibition assay. The University of Auckland. Dataset. https://doi.org/10.17608/k6.auckland.20760364.v1.

Wiles, Siouxsie (2022): Activity of the pure compounds Asperteretal B, Aspulvinone E, Aspulvinone G, Butyrolactone I, Butyrolactone II, Flavipesolide C, Terretonin, and Terretonin A isolated from the fungus Aspergillus terreus ICMP 477 against Mycobacterium abscessus and M. marinum. The University of Auckland. Dataset. https://doi.org/10.17608/k6.auckland.20126423.v1.

Wiles, Siouxsie (2022): Antibacterial activity of extracts from Aspergillus terreus ICMP 477 against Escherichia coli and Staphylococcus aureus. The University of Auckland. Dataset. https://doi.org/10.17608/k6.auckland.20113922.v1.

Funding

This work was supported by Cure Kids and New Zealand Carbon Farming. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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