Influence of Lymphangio vascular (V) and perineural (N) invasion on survival of patients with resected esophageal squamous cell carcinoma (ESCC): a single-center retrospective study

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Introduction

Materials and Methods

Patients and characteristics

Follow‑up

Pathological examination

Statistical analysis

Results

Patient characteristics and prevalence of LVI and PNI

Relationship of OS with LVI or/and PNI

Postoperative chemotherapy for patients with LVI or/and PNI

Univariate and multivariate analysis of survival

Risk factors related to patients with V1N1

Discussion

Supplemental Information

Raw data.

The clinical case data of a single center.

DOI: 10.7717/peerj.12974/supp-1

Statistical Reporting.

DOI: 10.7717/peerj.12974/supp-2

Additional Information and Declarations

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Chengke Xie performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.

Zhiyao Chen analyzed the data, prepared figures and/or tables, and approved the final draft.

Jie Xu performed the experiments, prepared figures and/or tables, and approved the final draft.

Zhiyong Meng analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Zhijun Huang conceived and designed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Jianqing Lin conceived and designed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

Ethics Committee of the Second Clinical Medical College Affiliated to Fujian Medical University.

Data Availability

The following information was supplied regarding data availability:

The raw data is available in the Supplemental File.

Funding

This work was supported by the Natural Science Research Foundation of Fujian Province: (No. 2019J01476 and No. 2021J01273), Medical Innovation Foundation of Fujian Province (No. 2019-CXB-19), High-level Talent Foundation of Quanzhou City (No. 2020C012R) and High-level Talent Innovation Foundation of Quanzhou City (No. 2017Z008). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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