A transcription factor signature predicts the survival of patients with adrenocortical carcinoma

View article
Bioinformatics and Genomics

Main article text

 

Introduction

Materials and Methods

Data collection and preprocessing

Survival analysis

Construction of ACC prognostic signature

mRNA expression of 13 TFs in ACC cell line

Gene set enrichment analysis (GSEA)

Results

Construction of the TF prognostic signature

TF signature risk score can predict prognosis of ACC patients

The risk score is an independent prognostic factor of ACC

The 13-TF signature is associated with cancer-related functions

Discussion

Additional Information and Declarations

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Jianyu Zhao conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Bo Liu performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.

Xiaoping Li conceived and designed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Data Availability

The following information was supplied regarding data availability:

All the raw data is available at TCGA (search term: ACC) and GEO: GSE19776.

Funding

The authors received no funding for this work.

2 Citations 1,766 Views 151 Downloads

Your institution may have Open Access funds available for qualifying authors. See if you qualify

Publish for free

Comment on Articles or Preprints and we'll waive your author fee
Learn more

Five new journals in Chemistry

Free to publish • Peer-reviewed • From PeerJ
Find out more