Prognostic impact of a lymphocyte activation-associated gene signature in GBM based on transcriptome analysis

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Bioinformatics and Genomics

Main article text

 

Introduction

Materials and Methods

Datasets description

Identifying the lymphocyte activation-associated gene signature

Statistical analysis

Results

Development of a prognostic signature related to lymphocyte activation

Prognostic value of the lymphocyte activation-associated gene signature in validation sets

The signature independently predicted overall survival of GBM patients

The differences in lymphocyte activity between the high- and low-risk groups of patients

Stratification analysis of the lymphocyte activation-associated gene signature

Comparison of prognostic power between clinical factors and the signature

Discussion

Supplemental Information

Supplemental Figures and Tables

DOI: 10.7717/peerj.12070/supp-1

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Yujia Lan conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Erjie Zhao and Xinxin Zhang performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft.

Xiaojing Zhu, Linyun Wan and Suru A performed the experiments, prepared figures and/or tables, and approved the final draft.

Yanyan Ping and Yihan Wang conceived and designed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Data Availability

The following information was supplied regarding data availability:

The data are available at TCGA (TCGA-GBM) and NCBI GEO (GSE16011 and GSE13041).

Funding

This work was supported by the Heilongjiang Postdoctoral Foundation (Grant No. LBH-Z19082) and the Special funds for the construction of higher education in Heilongjiang Province (Grant No. UNPYSCT-2018068). There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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