Homologous recombination repair rathway and RAD54L in early-stage lung adenocarcinoma

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Bioinformatics and Genomics

Main article text

 

Introduction

Materials and Methods

Patients and sample

Identification of differentially expressed genes and functional enrichment analysis in lung adenocarcinoma

Identification of differentially expressed genes and functional pathway enrichment analysis in T1 stage lung adenocarcinoma

Survival analysis and validation of significant pathway related differentially expressed genes

Statistical analysis

Results

Participants

Identification of differentially expressed genes and functional enrichment analysis in lung adenocarcinoma

Identification of differentially expressed genes and functional pathway enrichment analysis in T1 stage lung adenocarcinoma

Identification of homologous recombination pathway related genes and survival analysis

Discussion

Conclusions

Supplemental Information

Survival analysis of RAD54L in KM plot.

DOI: 10.7717/peerj.10680/supp-1

Survival analysis of RAD54L in GEPIA.

DOI: 10.7717/peerj.10680/supp-2

Additional Information and Declarations

Competing Interests

The authors declare that they have no competing interests.

Author Contributions

Shaopeng Zheng conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Lintong Yao performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Fasheng Li performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft.

Luyu Huang performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Yunfang Yu performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Zenan Lin performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Hao Li performed the experiments, analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Jin Xia performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Michael Lanuti performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Haiyu Zhou conceived and designed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Data Availability

The following information was supplied regarding data availability:

Raw data are available at The Cancer Genome Atlas (TCGA-LUAD: https://portal.gdc.cancer.gov/projects/TCGA-LUAD) and at NCBI GEO (GSE50081).

Funding

This study was funded by the Guangdong Province Medical Scientific Research Foundation (grant numbers B2018148), the Science and Technology Program of Guangzhou (grant numbers 201903010028), the Guangdong Provincial People’s Hospital Intermural Program (Grant Number KJ012019447), the Natural Science Foundation of Guangdong (Grant Number 2018A0303130113) and the Guangdong Medical University College Students Innovation Experiment Project, China (Grant number ZZZF001). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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