Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study

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Introduction

Methods

Patients screening and clinical data collection

Histologic evaluation

Statistical analyses

Results

Demographic and clinical data

The comparison of clinical characteristics between the normo-uricemia group and the hyperuricemia group

The comparisons of Oxford classification for IgAN between two groups

The comparison of different types of crescent lesions between the normo-uricemia group and the hyperuricemia group

The comparison of deposition of immune complexes and complements in renal biopsy between the two groups

The value of the SUA level in predicting renal prognosis

Discussion

Supplemental Information

The clinical data of patients in this study

DOI: 10.7717/peerj.10130/supp-1

The histologic evaluation data of patients in this study

DOI: 10.7717/peerj.10130/supp-2

The follow-up data of patients in this study

DOI: 10.7717/peerj.10130/supp-3

Additional Information and Declarations

Competing Interests

The authors declare there are no competing interests.

Author Contributions

Pingfan Lu conceived and designed the experiments, performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Xiaoqing Li conceived and designed the experiments, prepared figures and/or tables, and approved the final draft.

Na Zhu and Tianjing Zhang performed the experiments, prepared figures and/or tables, and approved the final draft.

Yuanjun Deng and Yang Cai performed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Lele Liu analyzed the data, authored or reviewed drafts of the paper, and approved the final draft.

Xueping Lin and Yiyan Guo analyzed the data, prepared figures and/or tables, and approved the final draft.

Min Han conceived and designed the experiments, authored or reviewed drafts of the paper, and approved the final draft.

Human Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

This study was approved by the medical ethics committee of Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology (TJ-IRB20180608).

Data Availability

The following information was supplied regarding data availability:

The raw data including clinical data, histologic evaluation data, and follow-up data are available in the Supplemental Files.

Funding

This study was supported by the National Natural Science Foundation of China (No.81770686, 81970591) and the independent innovation research funds project of Huazhong University of Science and Technology (No.2017KFYXJJ101). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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