Université de Sherbrooke
We are studying the immunological changes with aging. We are interested in the signal transduction of lymphocyte subpopulations (naïve, memory, …). We are investigating the early signalling changes in relation to changes in membrane composition (Lck, Csk, ..)
We are also studying the role of immunosenescence in the development and progression of Alzheimer disease (AD). We investigate the lymphocytes subpopulations, the macrophage functions and the role of chronic virus infection by Cytomegalovirus.
We are also interested in the role of immunosenescence in the tolerability of chemotherapy in elderly subjects. We study the functions, the phenotypic distribution and the signalling.
We study the role of the innate and adaptive immune response in the altered vaccine response of healthy elderly subjects and suffering from T2DM.
Techniques and equipment used: WB, FACScan, Confocal microscopy, Biochemistry, siRNA, ELISA, lipid rafts separation, etc
Intra- and extra-institutional collaborations: Immunology programme of the University of Sherbrooke, Tubingen, Gdansk, Detroit, Besançon, Paris.
Students: Four PhD students