Editor rating: 8 / 10Elena Papaleo –– This work reports a new method for template selection in antibody modeling using the RosettaAntibody framework. It has the potential to improve the accuracy of antibody structure prediction.
Editor rating: 8 / 10Jun Chen –– Multiple testing is a fundamental statistical problem in the big data era. Current practices do not consider the auxilary information accompanying the hypotheses, leading to less powerful mutliple testing precedures. This new procedure provides a novel, principled way to use the covariates in the framework of false discovery control, and is expected to be more powerful than the classic procedures when the covariate is informative.
Section Editor rating: 9 / 10Elena Papaleo –– Network theory applied to protein structural ensembles is a powerful paradigm to understand structure-function relationship. This work offers a new solid plugin to explore structures from simulations with graph analysis.
Section Editor rating: 8 / 10Elena Papaleo –– To experimentally identify functional short linear motifs (SLiMs) is challenged by their very low affinities. This paper introduces a new computational pipeline to assess how useful a certain protein-protein interaction dataset can be to capture SLiMs. I believe that it will be a very nice tool for many researchers working with protein-protein interactions with in-vitro and cellular assays, as well as for computational biologists.
Editor rating: 8 / 10Jürg Bähler –– A new method for reconstructing large transcriptional networks that removes some of the computational bottlenecks of such genome-scale analyses.
Editor rating: 9 / 10Pankaj Jaiswal –– This article on Torreya grandis (Taxaceae) an ancient conifer species that is endemic to southeast China provides an important insight into the population structure and distribution of the species. It also generated the genomic resources necessary to move forward the research on Torreya grandis.
Editor rating: 8 / 10Sven Rahmann –– This work presents the first bioinformatic solution for multi-locus sequence typing from long reads.
Editor rating: 9 / 10Min Zhao –– This is a good example to integrate data for lncRNAs in a specific cancer type.
Editor rating: 8 / 10Anthony Amend –– This paper highlights the use of a synthetic mock community as a standard to filter out bad quality data.
Editor rating: 9 / 10Hugo Sarmento –– Litterature text-mining to discover gene-gene interaction.
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