Bioinformatics and Genomics

Editors' Picks

Prognostic significance of PI3K/AKT/ mTOR signaling pathway members in clear cell renal cell carcinoma
Ferdinand Frauscher –– RCC is an important cancer - where treatment must be improved.
Dynamics of Influenza A (H5N1) virus protein sequence diversity
Yuriy Orlov –– Influenza A (H5N1) virus studies raise interesting problems in cross-disciplinary field of medicine, evolutionary and computational biology. The work has potential application for vaccine development.
Adaptations of data mining methodologies: a systematic literature review
Sebastian Ventura –– An interesting introduction to the topic. Of interest of people involved in the use and development of data mining algorithms.
Development and validation of a prognostic nomogram to predict overall survival and cancer-specific survival for patients with anaplastic thyroid carcinoma
Antonio Palazón-Bru –– A predictive model is a helpful tool for daily clinical practice.
High expression of stromal signatures correlated with macrophage infiltration, angiogenesis and poor prognosis in glioma microenvironment
Cheng Zhan –– This manuscript investigated the significance of stromal signatures in the glioma microenvironment.
Adaptive divergence for rapid adversarial optimization
Charles Elkan –– Generative adversarial networks (GANs) are an exciting development in machine learning, but it is hard to make them work in practice, and they can require a lot of training data. This research is a significant step towards making GANs more usable.
Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution
Andrew Gray –– This article addresses an important question about the heritability of pulmonary function, namely whether this is constant or varies by level of function. This could provide further insight into gene-environment interactions and potentially inform interventions aimed at reducing declines in pulmonary function.
The mitochondrial genome of Acrobeloides varius (Cephalobomorpha) confirms non-monophyly of Tylenchina (Nematoda)
Jia-Yong Zhang –– This research provide the complete mitochondrial genome of Acrobeloides varius.
The biomarkers of key miRNAs and target genes associated with acute myocardial infarction
Teresa Seccia –– LImited relevance.
The spindle assembly checkpoint and speciation
Ugo Bastolla –– This paper is important in the context of sympatric speciation, where it supports a speciation mechanism based on the variation of the number of chromosomes through sound molecular biology reasoning and mathematical modelling.
Bioinformatics and Genomics
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Section discussions

An article I handled as editor has been published today @PeerJCompSci https://t.co/1gpkJRTdzZ #Bioinformatics #DataMiningandMachineLearning

Good news in dark times: our new paper on wolf-sized otter (Sivaonyx) and leopard-sized wolverine (Plesiogulo) from early Pliocene of Langebaanweeg (South Africa) is published! https://t.co/1diQYLGG5I #Paleontology #Taxonomy @CoE_Palaeo @Iziko_Museums @UCT_news Art:Maggie Newman https://t.co/QU3l1sxckr

Status of coral reefs in Antigua & Barbuda: using data to inform management https://t.co/g1eA6NK5Cm @thePeerJ https://t.co/rRW6HG5zEG

Mountain goat survival and mortality during a period of increased puma abundance in the Black Hills, South Dakota https://t.co/2OhlO7xdEk @thePeerJ https://t.co/KjmKtdEXTz

Otra importante contribución al conocimiento de la ictiofauna neotropical publicado hoy en @thePeerJ: Evolución tectónica de la Cordillera de los Andes y su efecto en la diversificación del género Pseudopimelodus: @ https://t.co/BxFtZPXXwy #Biogeography #FreshwaterBiology