29 September 2023

Genome-wide identification of DUF506 gene family in Oryza sativa and expression profiling under abiotic stresses

"The authors put considerable effort into this study by identifying and classifying OsDUF506 OsDUF506s under drought, cold, and phosphorus deficiency stress. The manuscript was revised by two reviewers and suggested revision of the manuscript."

Elsayed Mansour, Handling Editor

28 September 2023

Identification of CDT1 as a prognostic marker in human lung adenocarcinoma using bioinformatics approaches

"The comments of the reviewer is helpful."

Peixin Dong, Handling Editor

15 September 2023

DEVOUR: Deleterious Variants on Uncovered Regions in Whole-Exome Sequencing

"Love the acronym! The functionality of this tool is not only for human disease, as demonstrated in the paper, but also other similar exome studies that seek to understand underlying changes leading to phyenotypic differences."

Brenda Oppert, Section Editor

11 September 2023

M6ATMR: identifying N6-methyladenosine sites through RNA sequence similarity matrix reconstruction guided by Transformer

"This study proposes a sequence-dependent-only RNA m6A modification site recognition method termed as M6ATMR that achieves promising performance when only utilizing sequences to identify m6A modification sites."

Liang Wang, Handling Editor

8 September 2023

Absence of enterotypes in the human gut microbiomes reanalyzed with non-linear dimensionality reduction methods

Alexander Bolshoy, Handling Editor

7 September 2023

The evolution of SARS-CoV-2 and the COVID-19 pandemic

"The study provides valuable insights into the worldwide endeavors in preventing epidemics and conducting scientific research on the evolution of the SARS-CoV-2 virus. It extensively examines the binding ability prediction and mutation rates of SARS-CoV-2, highlighting the adaptive relationship between humans and the virus. The findings derived from this comprehensive meta-analysis offer significant insights that can aid in the development of effective long-term strategies to combat human pathogens."

Mariella Pazzaglia, Handling Editor

18 August 2023

THAPBI PICT—a fast, cautious, and accurate metabarcoding analysis pipeline

"This study presents a novel and flexible pipeline for the objective analysis of metabarcode data, with user-friendly reports including Amplicon Sequence Variants read counts enabling custom graphs, as well as summary species lists per sample."

Xavier Pochon, Handling Editor

17 August 2023

Curcumin Chalcone Derivatives Database (CCDD): a Python framework for natural compound derivatives database

"Good one"

Nagarajan Raju, Handling Editor

16 August 2023

MMP12 serves as an immune cell–related marker of disease status and prognosis in lung squamous cell carcinoma

"The article titled "MMP12 serves as an immune cell–related marker of disease status and prognosis in lung squamous cell carcinoma" is of significant importance in the field of lung cancer research. This study explores the role of MMP12 as a potential marker for disease status and prognosis in lung squamous cell carcinoma, shedding light on the underlying mechanisms and potential therapeutic implications. The identification of reliable markers for disease monitoring and prognostic assessment is crucial for improving patient outcomes. By investigating the role of MMP12, the authors provide valuable insights into the intricate interplay between immune cells and cancer progression in lung squamous cell carcinoma. Such knowledge can aid in the development of targeted therapies and personalized treatment strategies. Furthermore, lung squamous cell carcinoma represents a significant healthcare burden globally. This study's findings have the potential to contribute to early detection, accurate disease monitoring, and prognostic stratification, ultimately improving patient management and survival rates. The impact of this research extends beyond the academic realm, holding promise for clinical applications and positively influencing the field of lung cancer research. Overall, the article addresses an important research gap and provides novel insights into the role of MMP12 as a disease status and prognostic marker in lung squamous cell carcinoma. Its publication will undoubtedly contribute to the existing body of knowledge and stimulate further investigations in this area, ultimately benefiting both researchers and clinicians in the fight against lung cancer."

Mahesh Gokara, Handling Editor

16 August 2023

Detection of single nucleotide polymorphisms in virus genomes assembled from high-throughput sequencing data: large-scale performance testing of sequence analysis strategies

"Detection of virus variants is important in many fields, including human health. The lessons learned here can translate to other viruses in different systems."

Brenda Oppert, Section Editor