Editor rating: 8 / 10Ugo Bastolla –– Due to the progress of sequencing technologies, the detection of single nucleotide variants offers unprecedented possibilities to investigate mutational processes and the mechanisms of cancer evolution. Nevertheless, to interpret this data is essential to control methodological errors. Smith, Carr and Eyre-Walker conclude that most sites with multiple single nucleotide variants in cancer genomes are a consequence of sequencing errors or errors in post-sequencing processing, a conclusion that is anticipated to stimulate further computational studies to disentangle genuine recurrent mutations from recurrent methodological errors and that may produce important methodological advances in the whole field of new generation sequencing.
Editor rating: 7 / 10Howard Young –– This article shows important differences in possible anti-stroke targets based on gender. Thus the management of this disease may need to be considered in the context of gender specific changes in gene expression.
Editor rating: 8 / 10Mario Negrello –– Given the ample relevance of cardiovascular problems, it is important to understand the factors contributing to the weakening of passive skeletal forces. The paper clearly indicates that it is muscle size that primarily relates to this weakening, suggesting particular treatment venues for effective treatment.
Editor rating: 7 / 10Ingrid Weiss –– This work is highly cross-disciplinary, aiming at developing and combining novel methodological approaches.
Editor rating: 7 / 10Timothy Read –– This is a further step forward toward industrial use of methogenic bacteria. The methodology and the use of genetic tools in this difficult organism although not novel, will be a useful reference.
Editor rating: 8 / 10Vijai Kumar Gupta –– Mss. is informative to the readers.
Editor rating: 8 / 10Tomas Hrbek –– important contribution to the systematics and classification of an enigmatic taxon; important contribution to evolution of "flight" and also biogeography; first tissue samples suitable for molecular analyses
Editor rating: 8 / 10Walter de Azevedo Jr. –– It brings new findings about AChE inhibition, which may contribute to design a new generation of AChE inhibitors.
Editor rating: 9 / 10Joan Heath –– The data-sets are extremely comprehensive (multiple time-points during development and postnatally) and the analyses are carefully performed. The data will be extremely useful to many mouse biologists, especially those working in the lung development field.
Editor rating: 8 / 10Yong Wang –– The authors investigated whether the left limb and the one of the right limb have the same statistical characteristics during functional tasks.
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