Bioinformatics and Genomics

Article commentary

In silico study on anti-Chikungunya virus activity of hesperetin

Editor rating: 7 / 10

Michael Buchmeier –– novel approach to Herpes antivirals
VSEARCH: a versatile open source tool for metagenomics

Editor rating: 10 / 10

Tomas Hrbek –– Potential applications span many disparate fields of science.
Molecular phylogeny of the megadiverse insect infraorder Bibionomorpha sensu lato (Diptera)

Editor rating: 8 / 10

Marcio Pie –– It provides an important advance toward our understanding of a highly diverse group of flies.
Monte Carlo simulation of OLS and linear mixed model inference of phenotypic effects on gene expression

Editor rating: 8 / 10

Dorothy Bishop –– On the one hand, it raises questions about a high-profile paper that has been the subject of considerable debate. But I think the statistical points made have considerably more application than to this one case, and the general issues raised about methods are important for the field. This is a highly technical paper that will only be understood by a minority of readers, but the inclusion of scripts to illustrate the different methods of analysis in the context of simulated data will be very helpful to anyone wishing to learn about this area
Boundary curves of individual items in the distribution of total depressive symptom scores approximate an exponential pattern in a general population

Editor rating: 7 / 10

Lucy Troup –– It attempts to define the measurement process of mood disorders more objectively
Mitochondrial DNA hyperdiversity and its potential causes in the marine periwinkle Melarhaphe neritoides (Mollusca: Gastropoda)

Editor rating: 7 / 10

Tim Collins –– This article addresses some very basic questions about population genetics, molecular evolution, and genetic diversity
The relationship between mobile phone location sensor data and depressive symptom severity

Editor rating: 7 / 10

Anthony Jorm –– This is a very new technology for assessing behavior change in depression.
RBioplot: an easy-to-use R pipeline for automated statistical analysis and data visualization in molecular biology and biochemistry

Editor rating: 7 / 10

Vsevolod Makeev –– This is a useful technical development, nothing shocking but convenient
Validation of picogram- and femtogram-input DNA libraries for microscale metagenomics

Editor rating: 9 / 10

Hauke Smidt –– The method described here allows to probe the metagenomes of low-biomass ecosystems at significantly reduced bias.
Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors?

Editor rating: 8 / 10

Ugo Bastolla –– Due to the progress of sequencing technologies, the detection of single nucleotide variants offers unprecedented possibilities to investigate mutational processes and the mechanisms of cancer evolution. Nevertheless, to interpret this data is essential to control methodological errors. Smith, Carr and Eyre-Walker conclude that most sites with multiple single nucleotide variants in cancer genomes are a consequence of sequencing errors or errors in post-sequencing processing, a conclusion that is anticipated to stimulate further computational studies to disentangle genuine recurrent mutations from recurrent methodological errors and that may produce important methodological advances in the whole field of new generation sequencing.

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116 days ago
At last! VSEARCH is here https://t.co/LerRP1DBVV via @thePeerJ