Bioinformatics and Genomics

Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors?

Editor rating: 8 / 10

Ugo Bastolla –– Due to the progress of sequencing technologies, the detection of single nucleotide variants offers unprecedented possibilities to investigate mutational processes and the mechanisms of cancer evolution. Nevertheless, to interpret this data is essential to control methodological errors. Smith, Carr and Eyre-Walker conclude that most sites with multiple single nucleotide variants in cancer genomes are a consequence of sequencing errors or errors in post-sequencing processing, a conclusion that is anticipated to stimulate further computational studies to disentangle genuine recurrent mutations from recurrent methodological errors and that may produce important methodological advances in the whole field of new generation sequencing.
Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets

Editor rating: 7 / 10

Howard Young –– This article shows important differences in possible anti-stroke targets based on gender. Thus the management of this disease may need to be considered in the context of gender specific changes in gene expression.
Muscle size explains low passive skeletal muscle force in heart failure patients

Editor rating: 8 / 10

Mario Negrello –– Given the ample relevance of cardiovascular problems, it is important to understand the factors contributing to the weakening of passive skeletal forces. The paper clearly indicates that it is muscle size that primarily relates to this weakening, suggesting particular treatment venues for effective treatment.
Comparative cephalopod shell strength and the role of septum morphology on stress distribution

Editor rating: 7 / 10

Ingrid Weiss –– This work is highly cross-disciplinary, aiming at developing and combining novel methodological approaches.
MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense

Editor rating: 7 / 10

Timothy Read –– This is a further step forward toward industrial use of methogenic bacteria. The methodology and the use of genetic tools in this difficult organism although not novel, will be a useful reference.
Rapid induction of GFP expression by the nitrate reductase promoter in the diatom Phaeodactylum tricornutum

Editor rating: 8 / 10

Vijai Kumar Gupta –– Mss. is informative to the readers.
Ancient phylogenetic divergence of the enigmatic African rodent Zenkerella and the origin of anomalurid gliding

Editor rating: 8 / 10

Tomas Hrbek –– important contribution to the systematics and classification of an enigmatic taxon; important contribution to evolution of "flight" and also biogeography; first tissue samples suitable for molecular analyses
Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking

Editor rating: 8 / 10

Walter de Azevedo Jr. –– It brings new findings about AChE inhibition, which may contribute to design a new generation of AChE inhibitors.
Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development

Editor rating: 9 / 10

Joan Heath –– The data-sets are extremely comprehensive (multiple time-points during development and postnatally) and the analyses are carefully performed. The data will be extremely useful to many mouse biologists, especially those working in the lung development field.
An investigation into the bilateral functional differences of the lower limb muscles in standing and walking

Editor rating: 8 / 10

Yong Wang –– The authors investigated whether the left limb and the one of the right limb have the same statistical characteristics during functional tasks.

Discussing these articles

'Probing the origins of human acetylcholinesterase inhibition..' published 1 year ago today in #OpenAccess @thePeerJ https://t.co/Qkc8UF1VRF

The Christian Science Monitor: "What is a Zenkerella?"
http://www.csmonitor.com/Science/2016/0817/What-is-a-Zenkerella

RedOrbit: "Scaly-tailed squirrel described as the ‘ultimate Pokémon’"
http://www.redorbit.com/news/science/1113415457/scaly-taled-squirrel-081616/#dv8TyHOpJmvZMUsw.99

CNN: "A real-life Pokemon: On the trail of a mysterious squirrel"
http://www.cnn.com/2016/08/16/health/ancient-squirrel-real-life-pokemon/

The Washington Post: "Scientists finally found Zenkerella, the world’s most mysterious mammal"
https://www.washingtonpost.com/news/speaking-of-science/wp/2016/08/16/scientists-finally-found-zenkerella-the-worlds-most-mysterious-mammal/