24 April 2025

Three distinct classes of myenteric ganglia in mice and humans: insights from quantitative analyses

"This study introduces a groundbreaking classification of myenteric ganglia, identifying three distinct types based on ganglionic area and intraganglion neuron count in both mouse and human colon tissues. By using whole-mount immunofluorescence and the K-means clustering algorithm, the research reveals structural diversity within the enteric nervous system, extending these classifications to early developmental stages in embryonic mice. This innovative approach not only enhances our understanding of myenteric ganglia's morphology but also opens new avenues for exploring their role in gastrointestinal disorders. The findings provide crucial insights into the ontogeny and potential dysfunctions of the enteric nervous system, making it a significant contribution to both basic science and clinical applications in gastroenterology."

Sonia Oliveira, Handling Editor

31 March 2025

Triple negative breast cancer cells acquire lymphocyte proteins and genomic DNA during trogocytosis with T cells

"Interesting study with important information on the role of trogocytosis in TNBC."

Vladimir Uversky, Section Editor

24 December 2024

Regulation of lymphoma in vitro by CLP36 through the PI3K/AKT/CREB signaling pathway

"This study addresses a gap in our understanding of lymphoma pathogenesis by investigating the role of CLP36 (PDLIM1) and its associated signaling pathway. The research provides experimental evidence demonstrating that CLP36 is upregulated in lymphoma and correlates with poor clinical outcomes. Through a series of well-designed functional experiments, the study reveals that CLP36 silencing reduces lymphoma cell survival and proliferation while promoting apoptosis. The investigation extends beyond mere phenotypic observations by elucidating the molecular mechanism, specifically the PI3K/AKT/CREB signaling axis, through which CLP36 exerts its effects. The findings establish a connection between CLP36 expression and the regulation of metastasis-associated proteins and apoptotic markers. The work employs standard methodological approaches and presents results that are consistent with current understanding of cancer cell biology. While the study focuses on fundamental molecular mechanisms, it may contribute to the identification of potential therapeutic targets in lymphoma treatment. The research adds to the growing body of knowledge regarding cytoskeletal protein involvement in cancer progression, though further validation in clinical settings would strengthen its translational relevance. Overall, this study provides a foundation for future investigations into the therapeutic potential of targeting the CLP36/PI3K/AKT/CREB axis in lymphoma treatment."

Fanglin Guan, Handling Editor

2 September 2024

A genetic investigation in five Chinese families with keratoconus

"Keratoconus is a common condition, and this paper looks into the possible genes that may be relevant."

Cong-Jun Li, Handling Editor

28 June 2024

Effect of glucocorticoid blockade on inflammatory responses to acute sleep fragmentation in male mice

"I feel this manuscript will be highly cited. Nice work and interesting results. "

Manuel Jimenez, Handling Editor

25 June 2024

The effects of exercise on FGF21 in adults: a systematic review and meta-analysis

Zekiye Altun, Handling Editor

23 May 2024

A murine model of hypertensive heart disease in older women

"Considering that hypertensive diseases are increasing worldwide, especially among women, murine models are necessary to address new therapeutic approaches. In this manuscript, the authors describe a new mouse model of cardiac hypertensive disease that includes age, timing of gonadectomy, and AngII infusion as possible biomarkers."

Tanya Camacho-Villegas, Handling Editor

15 January 2024

Proteomic detection of COX-2 pathway-related factors in patients with adenomyosis

Srinivas Sistla, Handling Editor

15 January 2024

Advances in macrophage and T cell metabolic reprogramming and immunotherapy in the tumor microenvironment

"The manuscript is an updated literature revision of the tumor microenvironment and its influence on cellular immune effectors. It also covers clinical trials of therapies to control cancer."

Héctor Mora-Montes, Handling Editor

2 January 2024

Chemical and spectroscopic characterization of (Artemisinin/Querctin/ Zinc) novel mixed ligand complex with assessment of its potent high antiviral activity against SARS-CoV-2 and antioxidant capacity against toxicity induced by acrylamide in male rats

"Based on this research, the novel Zn/Artemisinin/Quercetin mixed ligand complex holds great promise as a multifunctional therapeutic agent. It demonstrates potent antiviral activity against SARS-CoV-2, which is highly relevant in the context of the COVID-19 pandemic. Furthermore, the complex offers significant protective effects against Acy-induced toxicity and oxidative stress, highlighting its potential as an antioxidant agent. This study presents a comprehensive evaluation of the complex's antiviral and protective properties, providing valuable insights for the development of novel treatments targeting viral infections and oxidative stress-related disorders."

Sonia Oliveira, Handling Editor