Biochemistry, Biophysics and Molecular Biology

Editors' Picks

DeepBindPoc: a deep learning method to rank ligand binding pockets using molecular vector representation
Walter de Azevedo Jr. –– In this research paper, Zhang et al. report the development of a new computational tool to assess protein-ligand interaction using machine-learning techniques. This new approach can rank ligand-binding pockets using molecular vector representation. The predictive power of this new method has been determined using high-resolution crystallography structures of protein-ligand complexes. The authors demonstrated that their computational approach has a complementary advantage over the popular Fpocket score in many test cases.
In vitro histomorphometric comparison of dental pulp tissue in different teeth
Abhiram Maddi –– This article very nicely describes the methodology for isolation of dental pulp stem cells using histological analysis.
Upregulation of SPOCK2 inhibits the invasion and migration of prostate cancer cells by regulating the MT1-MMP/MMP2 pathway
Cheng-Chia Yu –– SPOCK2 is associated with the progression of prostate cancer and upregulation of SPOCK2 can inhibit invasion and metastasis.
Diagnostic performance of clinical properties and conventional magnetic resonance imaging for determining the IDH1 mutation status in glioblastoma: a retrospective study
Cheng-Chia Yu –– The combined use of patient age and tumor volume can enhance the diagnostic specificity of glioblastoma.
P5CR1 protein expression and the effect of gene-silencing on lung adenocarcinoma
Cheng-Chia Yu –– PYCR1 plays a critical role in cisplatin resistance of lung adenocarcinoma as to be a potential therapeutic target
Chemical composition, antioxidant and hepatoprotective activities of methanol extracts from leaves of Terminalia bellirica and Terminalia sericea (Combretaceae)
Maria Cristina Albertini –– The results published in this article are interesting and well analyzed with the use of innovative techniques.
Evaluation of buriti endocarp as lignocellulosic substrate for second generation ethanol production
Kalliat Valsaraj –– The use of lignocellulosic ethanol is a promising alternative to fossil fuels and this paper describes a unique method using a renewable material, viz., the fruit pericarp of buriti fruit, widely grown in sub-tropical areas.
Evolutionary persistence in Gunnera and the contribution of southern plant groups to the tropical Andes biodiversity hotspot
Luis Eguiarte –– Gunnera is a genus of plants that have fascinated scientist for a long time, in particular for the very large leaves of some species and because its symbiotic relationship with the nitrogen fixing cyanobacteria Nostoc. For a many years, some botanists suspected it to be a very old, primitive genus, perhaps basal in the phylogeny of the Angiosperms. While latter molecular phylogenies did not support this position, this paper shows that indeed Gunnera is an old genus, with a complex evolutionary and phylogeographic history, and a recent radiation in the Andes. All these new results are relevant for understanding why the Neotropics have so many plant species, more than any other similar region in the planet.
Molecular phylogenetics of swimming crabs (Portunoidea Rafinesque, 1815) supports a revised family-level classification and suggests a single derived origin of symbiotic taxa
Mohammad Shamsur Rahman –– very much fantastic work in the field of taxonomy, both in classical and molecular approach!
Introgression between ecologically distinct species following increased salinity in the Colorado Delta- Worldwide implications for impacted estuary diversity
Therese Markow –– It's a first and the data are very strong/
Biochemistry, Biophysics and Molecular Biology

Section discussions

Describen tres nuevas especies de tuco-tuco para la Patagonia. Una de ellas está exclusivamente en Península Valdés vía @thePeerJ

Otra importante contribución al conocimiento de la ictiofauna neotropical publicado hoy en @thePeerJ: Evolución tectónica de la Cordillera de los Andes y su efecto en la diversificación del género Pseudopimelodus: @ #Biogeography #FreshwaterBiology

My article has been published today in @thePeerJ #Biodiversity #ConservationBiology #Ecology #Forestry

A new chapter in our jellyfish benthic stages search published in @PeerJ! This paper by @ju_vbtv, @VanderveerHenkW and me documents first in situ find of polyps and podocysts of 2 common North Sea jellyfish species. Found hiding inside bivalve shells. 1/11