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The Association Between Subchorionic Haematoma and Pregnancy Outcomes: A Meta-Analysis and Systematic Review

obstetrics-and-gynecology

Abstract

Objective: The purpose of this study is to explore the association between subchorionic haematoma during pregnancy and pregnancy outcomes
Methods: We retrieved studies published up to 8 November 2025 concerning the association between subchorionic haematoma during pregnancy and pregnancy outcomes from PubMed, Web of Science, Embase, and the Cochrane Library databases. Data analysis was conducted using Stata 15 software, with effect sizes summarised using odds ratios (OR s ) and their 95% confidence intervals (CI s ).
Results: A total of 520 studies were retrieved through the search. Following screening, 36 studies were ultimately included, comprising 4 case-control studies and 32 cohort studies. The total sample size was 142,121 cases, univariate analysis of pregnant women with subchorionic haematoma revealed: a higher incidence of spontaneous abortion [OR=1.57, 95%CI(1.35, 1.83)], placental abruption [OR=1.98, 95%CI(1.14, 3.44)], fetal growth restriction [OR=2.16, 95%CI(1.39, 3.36)], oligohydramnios [OR=2.40, 95%CI (1.15, 5.02)], and gestational age <34 weeks [OR=1.71, 95%CI(1.37, 2.13)], shorter gestational age at delivery [OR=-0.20, 95%CI(-0.33, -0.07)], lower term delivery rate [OR=0.68, 95%CI(0.55, 0.83)], and reduced live birth rate [OR=0.62, 95%CI(0.46, 0.83)]. Multivariable Analysis revealed higher rates of spontaneous abortion [OR=1.47, 95%CI(1.10, 1.97)] and fetal growth restriction [OR=2.64, 95%CI(1.53, 4.53)], alongside a reduced live birth rate [OR=0.50, 95%CI(0.32, 0.80)].
Conclusion: Subchorionic haematoma during pregnancy is associated with an increased risk of adverse pregnancy outcomes, including spontaneous abortion, placental abruption, fetal growth restriction, oligohydramnios, and gestational age <34 weeks. It may also be associated with a reduction in gestational age at delivery, a lower rate of full-term delivery, and a lower live birth rate.
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