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The role of the SPHK-S1P-S1PRs signaling pathway in implantation

molecular-biology
gynecology-and-obstetrics
womens-health

Abstract

Sphingosine-1-phosphate (S1P) is an essential signaling molecule produced during sphingolipid metabolism to regulate a variety of biological processes inside and outside the cell, and it has a wide spectrum of biological interactions, regulating immune and vascular functions, and playing important roles in cell proliferation, migration, the immune system, and the cardiovascular system. The S1P signaling pathway has been thoroughly studied in the cardiovascular, immune and nervous systems, but its role in embryonic landing has been less well investigated. This article highlights the significant role of the S1P signaling pathway in peri-implantation angiogenesis and immune tolerance, in addition to its critical functions in promoting endothelial tissue metaplasia, uterine tissue growth and differentiation during pregnancy, and fertility preservation.
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