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The multifaceted roles of ependymin-related protein 1 in human physiology and disease: a literature review

biochemistry
developmental-biology
molecular-biology
oncology
medical-genetics

Abstract

The ependymin-related protein 1 (EPDR1) gene encodes a transmembrane protein that is synthesized and secreted by fibroblasts into the cerebrospinal fluid of teleosts at high concentrations. Recent transcriptomic and proteomic analyses have revealed its widespread expression across various human tissues, including the brain, adipose tissue, bone marrow, and reproductive organs. Accumulating evidence suggests that EPDR1 is involved in a range of physiological and pathological processes, such as adipocyte differentiation, osteoblastogenesis, and complex modulation of tumor cell behavior—acting as either a promoter or suppressor, depending on the cellular context. Despite its growing importance, the molecular mechanisms underlying EPDR1-mediated signaling are not yet fully understood. This review synthesizes current domestic and international literature to systematically delineate the multifaceted roles of EPDR1 in human diseases.
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