Academic Editor
Emanuele Paci
Summary
Associate Professor in Computational Biophysics at University of Leeds. From 2001 to 2004, Oberassistent at the Department of Biochemistry, University of Zurich.
Past or current institution affiliations
Work details
Associate Professor in Computational Biophysics
University of Leeds
Astbury Centre for Structural Molecular Biology
Most of my research in the past decade has been devoted to advance understanding of properties of macromolecules in biological contexts, by using computer simulations to establish a relation between physical models and experimental measurements. One unique property of biological polymers such as proteins and RNA is their ability to populate a state characterised by a precisely defined conformation, unlike any man-made polymers. Protein folding is one of the major focuses of our recent research, with a particular interest to the relation between folded structure, unfolding pathway and mechanical properties. Our theoretical and computational research in this field has had impact on the way experiments are performed and interpreted, while mechanical response is increasingly recognised as an essential part of many biological processes.
More recently we have turned our interests to the growth of bacterial pili, rational design of symmetric protein complexes such as capsids (with B. Turnbull), analysis of time resolved X-ray spectroscopy data (with A. Pearson), determination of structure and dynamics of macromolecular compounds from cryo-EM (with S. Muench) and hydrogen-exchange mass spectroscopy experiments (with R. Tuma).
PeerJ Contributions
Academic Editor on
June 11, 2018
159 downloads
1,023 views
May 3, 2016
5 citations
301 downloads
1,904 views
May 21, 2013
15 citations
1,198 downloads
8,892 views
February 12, 2013
22 citations
587 downloads
3,512 views