Associate Professor in Computational Biophysics at University of Leeds. From 2001 to 2004, Oberassistent at the Department of Biochemistry, University of Zurich.
Past or current institution affiliations
University of Leeds
Astbury Centre for Structural Molecular Biology
Most of my research in the past decade has been devoted to advance understanding of properties of macromolecules in biological contexts, by using computer simulations to establish a relation between physical models and experimental measurements. One unique property of biological polymers such as proteins and RNA is their ability to populate a state characterised by a precisely defined conformation, unlike any man-made polymers. Protein folding is one of the major focuses of our recent research, with a particular interest to the relation between folded structure, unfolding pathway and mechanical properties. Our theoretical and computational research in this field has had impact on the way experiments are performed and interpreted, while mechanical response is increasingly recognised as an essential part of many biological processes. More recently we have turned our interests to the growth of bacterial pili, rational design of symmetric protein complexes such as capsids (with B. Turnbull), analysis of time resolved X-ray spectroscopy data (with A. Pearson), determination of structure and dynamics of macromolecular compounds from cryo-EM (with S. Muench) and hydrogen-exchange mass spectroscopy experiments (with R. Tuma).
Academic Editor on
June 11, 2018
Mustapha Carab Ahmed, Elena Papaleo, Kresten Lindorff-Larsen
May 3, 2016
Jimmy C. Kromann, Anders S. Christensen, Qiang Cui, Jan H. Jensen
May 21, 2013
Matthew Z. Tien, Dariya K. Sydykova, Austin G. Meyer, Claus O. Wilke
February 12, 2013
Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome
Maria de Lourdes Coelho Ribeiro, Julio Espinosa, Sameen Islam, Osvaldo Martinez, Jayesh Jamnadas Thanki, Stephanie Mazariegos, Tam Nguyen, Maya Larina, Bin Xue, Vladimir N. Uversky