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All concerns of the reviewers were adequately addressed, and revised manuscript is acceptable now.
[# PeerJ Staff Note - this decision was reviewed and approved by Gwyn Gould, a PeerJ Section Editor covering this Section #]
Please answer all the queries of the reviewers and revise manuscript accordingly.
This is a well written review with helpful complementary figures.
Given vascular dysfunction, specifically large artery stiffening and endothelial dysfunction, are major antecedents to cardiovascular disease, this review would greatly benefit from discussion regarding the role of TFEB in these processes (there is literature to support this connection.
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The TFEB and cardiovascular disease review was already published in EBioMedicine in 2021 (https://www.thelancet.com/action/showPdf?pii=S2352-3964%2820%2930583-1). Some of the discussion in this manuscript is already clearly described in the previous EBioMEdicine paper. The authors need to add much information that is still not discussed yet in the previous paper.
Some of the previous studies mentioned by the authors are still in vitro studies. It’s better to add information in one summary of the role of TFEB in each CVD both in vitro and in vivo studies, so the readers will understand which role of TFEB still needs addition to vivo studies.
The conclusions are well stated.
The abbreviation of AS is not common, please write “atherosclerosis” instead of AS since it is already one word
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The abstract adequately introduces the subject, but it needs to add some important points from the conclusions.
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