Ipsita Mohanty

PeerJ Editor

Summary

Dr. Ipsita Mohanty is a Research Associate II at the Children's Hospital of Philadelphia Research Institute

Her current research focuses on investigating the molecular mechanisms of nitric oxide signaling pathway at the proteome levels using multipronged approach of mouse genetics, ex vivo mechanistic functional study as well as high throughput mass spectroscopy techniques.

Dr. Mohanty has expertise in pharmacology, physiology, and proteomics with emphasis in intracellular signal transduction and GPCR signaling directed towards designing therapeutic strategies for cardiovascular disorders. Technical cognizance encompasses fields of Smooth Muscle pharmacology, Integrative Physiology, Contraction Physiology, Proteomics, Biochemistry, Molecular Biology, Bioinformatic Data Analysis (and related softwares) for Mass Spectrometry data and In-Vivo skills.

Anatomy & Physiology Biotechnology Cell Biology Evidence Based Medicine Molecular Biology Pharmacology Sports Medicine Translational Medicine Veterinary Medicine

Editorial Board Member

PeerJ - the Journal of Life & Environmental Sciences

Work details

RESAERCH ASSOCIATE II

CHILDREN'S HOSPITAL OF PHILADELPHIA RESEARCH INSTITUTE

July 2020

NEONATOLOGY

I am investigating the molecular mechanism that governs nitric oxide signaling in the cardiovascular system. We use chemo selective, high-resolution, mass spectrometry based proteomic technologies to identify and quantify the two post-translational modifications protein phosphorylation and cysteine S-nitrosation, that constitute the two principal NO signaling pathways. My primary research interest emphasizes on expounding the regulatory role of G-protein coupled receptor & NO signaling on physiological and pathophysiological adaptations of the cardiovascular system. The overarching interest of my research is to gain a deeper understanding of the normal biology or physiology that maintains normal organ function in the cardiovascular and renal systems. I intend to understand how diseases occur and develop. In my research, I use genetically modified mice, which allows me to ask how these proteins are important, what role they play in normal cardiovascular and renal function, and how a lack of these proteins could contribute to diseases.