Jack C. Leo

Summary

I study bacterial pathogenesis, focusing on autotransporters of Gram-negative bacteria. These proteins are self-contained secretion systems and surface molecules that mediate a number of virulence functions. I aim to understand three aspects of autotransporter-mediated pathogenesis: 1) the mechanisms of virulence functions, 2) the biogenesis of autotransporters and 3) regulation of gene expression. All three are potential sites for intervention to prevent host colonisation and infection.

Biochemistry Biotechnology Infectious Diseases Microbiology Molecular Biology

Past or current institution affiliations