WANT A PROFILE LIKE THIS?
Create my FREE Plan Or learn about other options
Honoree Fleming
PeerJ Author
245 Points

Contributions by role

Preprint Author 245

Contributions by subject area

Cell Biology
Developmental Biology
Biochemistry
Histology

Honoree Fleming

PeerJ Author

Summary

With an interest in how hormones effect dramatic structural changes in human endometrial cells, I began studying cell lines in vitro more that three decades ago. Differentiation in a monolayer leading to polarized cells characteristic of domes and eventually to gland evagination was documented for Ishikawa cells in 1998. Studying differentiation provided results of interest to cancer biologists. Hopefully, PeerJ will be a forum for communicating those results to other scientists.

Biochemistry Cell Biology

Editing Journals

Past or current institution affiliations

Castleton State College

Work details

Director

CancerCellsinVitro.com

Websites

  • Exploring cancer cell types in vitro

PeerJ Contributions

  • Preprints 7
August 12, 2019 - Version: 1
Tubular membranes extended between monolayer cells, from solid spheroids, and from clustered hollow spheroids in Ishikawa endometrial cell cultures can carry chromatin granules and mitonucleons
Honoree Fleming
https://doi.org/10.7287/peerj.preprints.27895v1
January 3, 2019 - Version: 1
Chromatin streaming from giant polyploid nuclei in Ishikawa endometrial hollow spheroids results in the amitotic proliferation of nuclei that fill the spheroid envelope
Honoree Fleming
https://doi.org/10.7287/peerj.preprints.27463v1
March 29, 2018 - Version: 1
Polyploid monolayer Ishikawa endometrial cells form unicellular hollow spheroids capable of migration
Honoree Fleming
https://doi.org/10.7287/peerj.preprints.26793v1
February 9, 2016 - Version: 1
Chomatin mass from previously aggregated, pyknotic, and fragmented monolayer nuclei is a source for dome cell nuclei generated by amitosis: Differentiation of Ishikawa Domes, Part 3
Honoree Fleming
https://doi.org/10.7287/peerj.preprints.1730v1
February 9, 2016 - Version: 1
Pyknotic chromatin in mitonucleons elevating in syncytia undergo karyorhhexis and karyolysis before coalescing into an irregular chromatin mass: Differentiation of Ishikawa Domes, Part 2
Honoree Fleming
https://doi.org/10.7287/peerj.preprints.1729v1
February 9, 2016 - Version: 1
Mitonucleons formed during differentiation of Ishikawa endometrial cells generate vacuoles that elevate monolayer syncytia: Differentiation of Ishikawa domes, Part 1
Honoree Fleming
https://doi.org/10.7287/peerj.preprints.1728v1
December 31, 2014 - Version: 1
Unusual characteristics of opaque Ishikawa endometrial cells include the envelopment of chromosomes with material containing endogenous biotin in the latter stages of cytokinesis
Honoree Fleming
https://doi.org/10.7287/peerj.preprints.772v1