Xuhui Feng

Xuhui Feng


Major Publications
Jin Yang, Konstantinos Savvatis, Jong Seok Kang,…,Xuhui Feng, Qiong Zhou, Ching Shang, Praveen Kumar Dillon Phan… Ching-Pin Chang (2016). Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment. Nat Commun.7:13710.
Jin Yang, Xuhui Feng, Qiong Zhou, Wei Cheng, Ching Shang, Pei Han, Chiou-Hong Lin, Huei-Sheng Vincent Chen, Thomas Quertermous, and Ching-Pin Chang (2016). Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex. PNAS 113 (38) E5628-E5635.
Jin LH*, Feng XH*,Rong H, Pan ZF, Inaba Y, Qiu L, Zheng WL, Lin SC, Wang R,Wang Z, Wang SS, Liu HY, Li S, Xie W and Li Y (2013). The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism. Nat Commun.4: 1937. (*co-first author)
ZhengWL*, Feng XH*, Qiu L, Pan ZF, Wang R, Lin SC, Hou D, Jin LH, Li Y(2013). Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia. 56(2):401-11. (*co-first author)

Cardiology Cell Biology Developmental Biology Diabetes & Endocrinology Gastroenterology & Hepatology Immunology Metabolic Sciences Molecular Biology Pharmacology Translational Medicine

Work details


krannert institute of cardiology
We have generated a mouse model of cardiomyopathy and a mouse model that allows us to study the signaling events during the repair process following vascular injury such as balloon angioplasty. These models are directly relevant to a specific type of human congestive heart failure and the restenosis following angioplasty and stenting seen in clinical cardiology. We are investigating the pathogenesis of cardiomyopathy and the mechanisms of vascular restenosis following injury

PeerJ Contributions