Vinesh Vinayachandran

Summary

Determinants of Nucleosome Positioning: In a novel approach, my research has uncovered that DNA sequence influences nucleosome positioning, and under specific conditions, transcription factors and chromatin remodelers can induce nucleosome movement, shedding new light on this fundamental process.
Transcriptional Dynamics During Stress Response: Cells adapt to stress by altering gene expression, involving changes in the preinitiation complex. These changes persist post-stress, indicating cellular memory and potential early disease diagnosis applications.
Role of Chromatin Remodelers in Transcription: Chromatin remodelers move nucleosomes to allow DNA access for transcription. My research mapped their preferences across the genome, enhancing our understanding of gene expression and related diseases.
Nucleosome-Free Region (NFR) and Chromatin Remodelers: NFRs are nucleosome gaps that aid gene regulation. My work identified specific remodelers that recognize NFRs and form unique subunits, offering potential disease treatment insights.
Transcription Biology of Innate Immune Cells: Obesity involves inflammation (metaflammation) influenced by the immune system. Fatty diets downregulate myeloid KLF2, increasing inflammation and metabolic issues. Understanding KLF2 pathways could lead to new obesity treatments.
Transcription Factors Governing Vascular Function and Heart Diseases: KLF2 and KLF4 are vital for endothelial cell function, preventing vascular leak and coagulopathy. My research explored their regulatory mechanisms, aiming to uncover targets for vascular disease treatment.
Transcriptional Regulator KLF15 in Lipid Metabolism: KLF15 regulates lipid metabolism in muscle cells. Its deletion causes lipid processing issues and metabolic disorders, suggesting potential treatments for obesity and diabetes.
Epigenetic Regulation in Cardiovascular Health: Environmental factors affect cardiovascular gene expression through epigenetic modifications. I studied these effects, particularly on metabolic diseases, to identify therapeutic targets.
Environmental Epigenetics: My research has shown that air pollution causes temporary changes in DNA and epigenetic marks. However, the good news is that these changes are reversible upon cessation of exposure, underscoring the potential for interventions to mitigate the health impact of pollution.

Agricultural Science Biochemistry Biotechnology Cell Biology Computational Biology Environmental Health Genetics Genomics