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I study the mechanisms that promote motivated behavior, especially the compulsive drives that epitomize addiction. I combine sophisticated animal models to study substance abuse disorders with optogenetics, in vitro electrophysiology and shRNAs to identify drug-related changes that enhance pathological intake. I also seek to determine if depression and excessive anxiety, often co-morbid with alcoholism, are mediated by these signaling pathways and by dopamine and neuro-peptides.
Assistant Adjunct Professor
Gallo Research Center, Univ. of Calif. San Francisco
April 9, 2013
MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro
F Woodward Hopf, Taban Seif, Shinjae Chung, Olivier Civelli