Shobana Navaneethabalakrishnan

PeerJ Editor & Reviewer

Summary

I received my PhD in Reproductive Endocrinology from University of Madras, India where I studied the molecular mechanism underlying the repression of follicle stimulating hormone receptor and androgen receptor in Sertoli cells of F1 progeny rats with gestational exposure to hexavalent chromium. I have successfully attained inter-laboratory collaboration to study the effect of gestational exposure to excess hexavalent chromium on insulin signaling molecules and glucose homeostasis in F1 progeny rats. Currently, my research focus is to understand the role of gonadal macrophage polarization in reproductive dysfunction associated with hypertension in both men and women.

Andrology Biotechnology Cardiology Diabetes & Endocrinology Gynecology & Obstetrics Immunology Molecular Biology Nephrology Obesity Toxicology Translational Medicine Urology Women's Health

Editing Journals

PeerJ - the Journal of Life & Environmental Sciences

Past or current institution affiliations

Texas A&M University Libraries

Work details

Postdoctoral Research Associate

Texas A&M University

Medical Physiology

Currently, my research is primarily focused on the molecular mechanism underlying reproductive dysfunction associated with hypertension (HTN). We have recently reported that salt-sensitive HTN promotes increase in pro-inflammatory macrophages, inflammation and lymphangiogenesis in the gonads and is associated with reproductive dysfunction. Our lab is also focused on the molecular mechanisms involved in the lymphatic endothelial dysfunction caused by various hypertensive stimuli. We have shown that a kidney-targeted nanoparticle that augments renal lymphangiogenesis reduces blood pressure in mice. Our research goals also includes the effect of time-restricted feeding on the renal immune cells, lymphatics and blood pressure.

Websites

Google Scholar

PeerJ Contributions

Edited 7

Academic Editor on

February 3, 2023

Data processing choices can affect findings in differential methylation analyses: an investigation using data from the LIMIT RCT

Jennie Louise, Andrea R. Deussen, Jodie M. Dodd

https://doi.org/10.7717/peerj.14786

January 30, 2023

Prediction model for missed abortion of patients treated with IVF-ET based on XGBoost: a retrospective study

Guanghui Yuan, Bohan Lv, Xin Du, Huimin Zhang, Mingzi Zhao, Yingxue Liu, Cuifang Hao

https://doi.org/10.7717/peerj.14762

January 18, 2023

Acteoside alleviates UUO-induced inflammation and fibrosis by regulating the HMGN1/TLR4/TREM1 signaling pathway

Yan Mao, Jiali Yu, Jingjing Da, Fuxun Yu, Yan Zha

https://doi.org/10.7717/peerj.14765 PubMed 36691481

January 17, 2023

Prenatal diagnosis of fetuses conceived by assisted reproductive technology by karyotyping and chromosomal microarray analysis

Huan Guo, Rui Sheng, Xiu Zhang, Xuemei Jin, Wenjing Gu, Ting Liu, Haixin Dong, Ran Jia

https://doi.org/10.7717/peerj.14678 PubMed 36684682

January 10, 2023

Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration

Deokho Lee, Ayaka Nakai, Yukihiro Miwa, Kazuno Negishi, Yohei Tomita, Toshihide Kurihara

https://doi.org/10.7717/peerj.14611 PubMed 36643635

December 2, 2022

M1 macrophage-derived extracellular vesicle containing tsRNA-5006c promotes osteogenic differentiation of aortic valve interstitial cells through regulating mitophagy

Hao Xia, Mingjian Gao, Jun Chen, Guanshen Huang, Xiuting Xiang, Yuyan Wang, Zhaohui Huang, Yongchun Li, Shuang Su, Zewei Zhao, Qingchun Zeng, Yunjun Ruan

https://doi.org/10.7717/peerj.14307 PubMed 36518291

October 27, 2022

Retrospective study of intrapartum fever in term pregnancies and adverse obstetric and neonatal outcomes

Hongmin An, Wei Zheng, Qinghua Zhu, Haiyan Wen

https://doi.org/10.7717/peerj.14242 PubMed 36320562