UNC Chapel Hill
As members of the ENCODE (ENCyclopedia Of DNA Elements) Consortium, we are contributing to the goal of identifying all functional elements in the human genome. Along with the Drs. Crawford and Lieb, our group includes Vishy Iyer’s lab at Univ Texas-Austin, and Ewan Birney’s lab at the EBI. Our group has created open chromatin maps of the human genome in several diverse cell types with chromatin immunoprecipitation (ChIP) data providing initial functional annotations for these regions. We are also investigating allele-specific regulatory regions identified using sequences from the open chromatin and ChIP experiments. We have and continue to develop computational methods to integrate and analyze sequence data DNase I hypersensitivity, FAIRE, and ChIP experiments. We are currently focused on understanding chromatin changes between related cell types such as myoblasts and myotubes, prostate cancer with and without androgen stimulation, and between common cell types across multiple primate species.