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Section Highlights View all Bioinformatics and Genomics articles

Network neighborhood operates as a drug repositioning method for cancer treatment
"Drug repositioning or repurposing is an important possibility to widen the therapeutic choices available yet identifying drugs that can potentially be repurposed is anything but easy. In silico detection of candidate drugs is therefore an important step in this process and the present study offers a new tool to do this."
Ulrich Pfeffer, Handling Editor
Development of a circHIPK3-based ceRNA network and identification of mRNA signature in breast cancer patients harboring BRCA mutation
"This study has deepened our understanding of the molecular mechanisms of breast cancer."
Peixin Dong, Handling Editor
Multi-Object Tracking in Heterogeneous environments (MOTHe) for animal video recordings
"MOTHe is a promising improvement to track movement of animals, demonstrated with a small wasp and larger antelope, and has training to improve detection."
Brenda Oppert, Handling Editor
Investigating the sequence landscape in the Drosophila initiator core promoter element using an enhanced MARZ algorithm
"Results presented in this article might aid design and analysis of new bioinformatics algorithms to promotor sequence prediction and analysis"
Rudi Ettrich, Handling Editor
Weighted multiple testing procedures in genome-wide association studies
"The ability to identify SNPs in rare variants has cross-discipline applications."
Brenda Oppert, Handling Editor
Retrospective study of transcriptomic profiling identifies Thai triple-negative breast cancer patients who may benefit from immune checkpoint and PARP inhibitors
"The manuscript demonstrates a way to further characterize tumor types that will lead to better treatments, and has implications for other disease tissue."
Brenda Oppert, Handling Editor
Ferroptosis-associated gene CISD2 suppresses colon cancer development by regulating tumor immune microenvironment
"The study on the prognostic value of CISD2 in colorectal adenocarcinoma will be helpful for clinical prevention and treatment."
Yuzhen Xu, Handling Editor
The effect of FMT and vitamin C on immunity-related genes in antibiotic-induced dysbiosis in mice
"More studies are needed to investigate the efficacy of antibiotics in dysbiosis."
Mehmet Burak Ateş, Handling Editor
CPJSdraw: analysis and visualization of junction sites of chloroplast genomes
Ajit Passari, Handling Editor
Topological feature generation for link prediction in biological networks
"The proposed embedding method is faster than other methods."
Rajesh Bhardwaj, Handling Editor
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