Bioinformatics and Genomics

Muscle size explains low passive skeletal muscle force in heart failure patients

Editor rating: 8 / 10

Mario Negrello –– Given the ample relevance of cardiovascular problems, it is important to understand the factors contributing to the weakening of passive skeletal forces. The paper clearly indicates that it is muscle size that primarily relates to this weakening, suggesting particular treatment venues for effective treatment.
Comparative cephalopod shell strength and the role of septum morphology on stress distribution

Editor rating: 7 / 10

Ingrid Weiss –– This work is highly cross-disciplinary, aiming at developing and combining novel methodological approaches.
MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense

Editor rating: 7 / 10

Timothy Read –– This is a further step forward toward industrial use of methogenic bacteria. The methodology and the use of genetic tools in this difficult organism although not novel, will be a useful reference.
Rapid induction of GFP expression by the nitrate reductase promoter in the diatom Phaeodactylum tricornutum

Editor rating: 8 / 10

Vijai Kumar Gupta –– Mss. is informative to the readers.
Ancient phylogenetic divergence of the enigmatic African rodent Zenkerella and the origin of anomalurid gliding

Editor rating: 8 / 10

Tomas Hrbek –– important contribution to the systematics and classification of an enigmatic taxon; important contribution to evolution of "flight" and also biogeography; first tissue samples suitable for molecular analyses
Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking

Editor rating: 8 / 10

Walter de Azevedo Jr. –– It brings new findings about AChE inhibition, which may contribute to design a new generation of AChE inhibitors.
Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development

Editor rating: 9 / 10

Joan Heath –– The data-sets are extremely comprehensive (multiple time-points during development and postnatally) and the analyses are carefully performed. The data will be extremely useful to many mouse biologists, especially those working in the lung development field.
An investigation into the bilateral functional differences of the lower limb muscles in standing and walking

Editor rating: 8 / 10

Yong Wang –– The authors investigated whether the left limb and the one of the right limb have the same statistical characteristics during functional tasks.
The core clock gene Per1 phases molecular and electrical circadian rhythms in SCN neurons

Editor rating: 7 / 10

Michael Henson –– This article further clarifies the relationship between neural firing and core clock activity in the SCN.
Computational fluid dynamics modelling of left valvular heart diseases during atrial fibrillation

Editor rating: 7 / 10

Ebba Brakenhielm –– This work provides a novel integrated model for how valvular stenosis (aortic vs mitral) influence hemodynamics in the setting of atrial fibrillation.

Discussing these articles

'Probing the origins of human acetylcholinesterase inhibition..' published 1 year ago today in #OpenAccess @thePeerJ https://t.co/Qkc8UF1VRF

The Christian Science Monitor: "What is a Zenkerella?"
http://www.csmonitor.com/Science/2016/0817/What-is-a-Zenkerella

RedOrbit: "Scaly-tailed squirrel described as the ‘ultimate Pokémon’"
http://www.redorbit.com/news/science/1113415457/scaly-taled-squirrel-081616/#dv8TyHOpJmvZMUsw.99

CNN: "A real-life Pokemon: On the trail of a mysterious squirrel"
http://www.cnn.com/2016/08/16/health/ancient-squirrel-real-life-pokemon/

The Washington Post: "Scientists finally found Zenkerella, the world’s most mysterious mammal"
https://www.washingtonpost.com/news/speaking-of-science/wp/2016/08/16/scientists-finally-found-zenkerella-the-worlds-most-mysterious-mammal/