Biochemistry, Biophysics and Molecular Biology

Editors' Picks

Contributions of Latin American researchers in the understanding of the novel coronavirus outbreak: a literature review
Robert Winkler –– The review demonstrates the general performance of scientific research in Latin America in response to a critical threat. Thus, it might influence political decision-makers.
Luteolin attenuates doxorubicin-induced cardiotoxicity by modulating the PHLPP1/AKT/Bcl-2 signalling pathway
Cheng-Chia Yu –– Luteolin administration as novel and natural therapeutic to protect against chemotherapy-induced cardiotoxicity
Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway
Jesús Campos-García –– Scientific knowledge about the mechanisms of action of natural products is relevant to understand their ancient use in the treatment of diseases. Deep in the molecular mechanisms involved is a scientific challenge.
CoproID predicts the source of coprolites and paleofeces using microbiome composition and host DNA content
Antonio Amorim –– The novel approach is applicable to various fields.
DeepBindPoc: a deep learning method to rank ligand binding pockets using molecular vector representation
Walter de Azevedo Jr. –– In this research paper, Zhang et al. report the development of a new computational tool to assess protein-ligand interaction using machine-learning techniques. This new approach can rank ligand-binding pockets using molecular vector representation. The predictive power of this new method has been determined using high-resolution crystallography structures of protein-ligand complexes. The authors demonstrated that their computational approach has a complementary advantage over the popular Fpocket score in many test cases.
Icariin affects cell cycle progression and proliferation of human retinal pigment epithelial cells via enhancing expression of H19
Diego Wilke –– Natural products are a prolific source if medicines highly relevant to treat countless human diseases. In this paper, icaridin effects suitable to treat retinopathy is depicted.
Homeoprotein OTX1 and OTX2 involvement in rat myenteric neuron adaptation after DNBS-induced colitis
Jerson Silva –– The study evidences that colitis up-regulates OTX1 and OTX2 in myenteric plexus, with a potential participation in the inflammatory-related myenteric ganglia remodeling processes.
Flavonoids from Epimedium pubescens: extraction and mechanism, antioxidant capacity and effects on CAT and GSH-Px of Drosophila melanogaster
Chin Ping Tan –– This paper highlights work related to ultrasound extraction of flavonoids from Epimedium pubescens and subsequent evaluation on antioxidant properties and effect of the extract on fruit flies.
Prognostic factors and survival outcomes according to tumor subtype in patients with breast cancer lung metastases
Walter de Azevedo Jr. –– In this paper, the authors described a study focused on prognosis of breast cancer lung metastases. The manuscript brings analysis of data obtained from 6516 patients with lung metastatic breast cancer. Their results gave new insight into the incidence, prognostic assessment, and risk stratification of breast cancer with lung metastases, enriching the study of the epidemiology of this occurrence.
In vitro histomorphometric comparison of dental pulp tissue in different teeth
Abhiram Maddi –– This article very nicely describes the methodology for isolation of dental pulp stem cells using histological analysis.
Biochemistry, Biophysics and Molecular Biology

Section discussions

An article I handled as editor has been published today @thePeerJ "Contributions of Latin American researchers in the understanding of the novel coronavirus outbreak: a literature review" About 2.7 ± 0.6% of the publications came from this region.

Isolation, characterization, and cryopreservation of collared peccary skin-derived fibroblast cell lines @thePeerJ

Ars Technica: "Archaeologists now have a handy new tool for analyzing paleo poop"