Biochemistry, Biophysics and Molecular Biology

How well do force fields capture the strength of salt bridges in proteins?

Editor rating: 8 / 10

Emanuele Paci –– The paper provides a test case for testing polarizable force fields for the simulations of proteins.
An improved primer set and amplification protocol with increased specificity and sensitivity targeting the Symbiodinium ITS2 region

Editor rating: 8 / 10

Tomas Hrbek –– Optimized protocol for amplification of Symbiodinium ITS2 region, that makes great strides towards generating reproducible and comparable data across a diversity of studies.
Characterization of antimicrobial resistance genes in Haemophilus parasuis isolated from pigs in China

Editor rating: 8 / 10

Sheng Chen –– A detail characterization of antibiotic resistance in Haemophilus parasuis, which is a very important animal pathogen. No much research work has been done in this organism in particular in the area of antimicrobial resistance.
The little shrimp that could: phylogeography of the circumtropical Stenopus hispidus (Crustacea: Decapoda), reveals divergent Atlantic and Pacific lineages

Editor rating: 8 / 10

Xavier Pochon –– This study provides the first range-wide phylogeographic study of the banded coral shrimp S. hispidus, extending across more than 27,000 km of the globe. Coalescence analysis brings evidence that an isolated Indo-Pacific lineage evolved from a rare dispersal event from the Atlantic around South Africa via the Benguela Current, thereby colonizing the Indian and Pacific Oceans, followed by dispersal across the Indo-Pacific in the last 200,000 years. Surprisingly, this benthic coral reef associated shrimp shows a single haplotype dominating the largest continuous tropical oceanic expanse on the planet.
Human anti-HIV IgM detection by the OraQuick ADVANCE® Rapid HIV 1/2 Antibody Test

Editor rating: 8 / 10

Fernando Spilki –– The manuscript describes a new technique for quick detection of anti-HIV1/2 IgM.
Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding

Editor rating: 8 / 10

Jerson Silva –– This work has the novelty to provide a detailed investigation of structure – thermodynamics relationship of the protein recognition process.
Complex versus simple models: ion-channel cardiac toxicity prediction

Editor rating: 8 / 10

Heiko Enderling –– This article discusses the contributions of quantitative models in predicting biology, and makes an important point about the balance of simplicity/complexity/accuracy/usefulness of biophysical models. If simple models capture biological complexity, the use of more detailed models must be properly justified.
Development of an RNA interference (RNAi) gene knockdown protocol in the anaerobic gut fungus Pecoramyces ruminantium strain C1A

Editor rating: 8 / 10

Alexandra Lusser –– The article describes the development of a new method in this field that should facilitate future research in this area.
Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition

Editor rating: 8 / 10

Ayyalusamy Ramamoorthy –– The findings on the membrane domain localization is important and useful.
Exosomal microRNA remodels the tumor microenvironment

Editor rating: 8 / 10

Maria Cristina Albertini –– Exosomal microRNAs are becoming interesting comunication mechanisms during pathogenesis.

Discussing these articles

to all peeps doing #Symbiodinium ITS2 typing: check out the new & improved primer pair and robust PCR protocol .. works well in particular for non-host environments https://t.co/zz8DZyLON3 .. ground truthing & future proofing ITS2 @TaraExpeditions @thePeerJ @KAUST_News

Our research has been peer reviewed and now appears in print. We are pleased to confirm that OraQuick Advance HIV ½ Antibody Test has been proven to detect IgM Antibodies thus allowing our customers to reliably detect HIV earlier i…https://t.co/IlqZOUgiPq https://t.co/cAAUzCceR2

The little shrimp that could: phylogeography of the circumtropical Stenopus hispidus (Crustacea: Decapoda), reveals divergent Atlantic and Pacific lineages https://t.co/TXOB7dyxro https://t.co/QkZN9Zfxz0

new publication: https://t.co/MONo6omrX3 a comprehensive analysis on how a well-defined simple heuristic is as good (if not better) than complex mathematical models, used by FDA and bloated pharma companies, in ion-channel safety pharmacology #mathbiology

148 days ago
#Exosomal #microRNA remodels the #tumor microenvironment. https://t.co/sVcjLC25lk https://t.co/4fcM1emOTS