Biochemistry, Biophysics and Molecular Biology

Editors' Picks

Histopathological analysis of zebrafish after introduction of non-biodegradable polyelectrolyte microcapsules into the circulatory system
Vladimir Uversky –– This study is of great interest and importance for specialists in aquatic science
Porphyromonas gingivalis lipopolysaccharide promotes T-hel per17 cell differentiation by upregulating Delta-like ligand 4 expression on CD14+ monocytes
Joseph Gillespie –– Zhang et al. describe the role of monocytes and T-cell in the progression of periodontal disease, one of the most important oral disease.
Effect of leaf position and days post-infiltration on transient expression of colorectal cancer vaccine candidate proteins GA733-Fc and GA733-FcK in Nicotiana benthamiana plant
Abhiram Maddi –– Production of vaccines in plants may be an important approach in the future as we deal with the current pandemic.
Cinnamtannin B1 attenuates rosacea-like signs via inhibition of pro-inflammatory cytokine production and down-regulation of the MAPK pathway
Consolato Sergi –– Cinnamtannin B1 is a tannin found in Cinnamomum verum and has been found to have pharmacological effects in treating type 2 diabetes mellitus and insulin resistance. This article brilliantly targets the attenuation of rosacea-like symptoms by investigating the MAPK pathway.
Improved plaque assay for human coronaviruses 229E and OC43
Rogerio Sotelo-Mundo –– The method proposed by Bracci et al. provides a practical assay to evaluate antiviral compounds using a cellular assay that does not rely on reverse transcriptase-PCR. The use of milder human coronavirus strains HCoV-229E and OC43 in BSL-2 biosafety conditions will permit the evaluation of potential drugs in an in vitro antiviral assay.
In vitro and in vivo hypolipidemic properties of the aqueous extract of Spirulina platensis, cultivated in colored flasks under artificial illumination
Thiago Parente –– It provides a relevant contribution to the production of hypolipidemic compounds from cultivated Spirulina algae.
Investigation of acute-phase proteins and cytokines response in goats with contagious caprine pleuropneumonia with special reference to their diagnostic accuracy
Korakot Nganvongpanit –– Acute-phase proteins had valued diagnostic potentialities in response to infection. This study had evaluated the diagnostic accuracy of selected acute-phase proteins and proinflammatory cytokines in goats with contagious caprine pleuropneumonia. The result of this study endorses the significance of selected acute-phase proteins and proinflammatory cytokines as additional screening diagnostic parameters for naturally occurring contagious caprine pleuropneumonia in goats.
Differentially expressed serum proteins in children with or without asthma as determined using isobaric tags for relative and absolute quantitation proteomics
Abhiram Maddi –– This article is probably one of the very few to examine differentially expressed serum proteins in asthma patients. It may provide significant information related to diagnosis and therapy.
Construction of fibronectin conditional gene knock-out mice and the effect of fibronectin gene knockout on hematopoietic, biochemical and immune parameters in mice
Howard Young –– It provides new data on the role of fibronecttin on host systems, with an emphasis on immune function
Differences in small noncoding RNAs profile between bull X and Y sperm
Korakot Nganvongpanit –– This work has shown the different sncRNA profiles of X and Y sperm in cattle and understanding of their potential roles in the regulation of sex differences in sperm and early embryonic development.
Biochemistry, Biophysics and Molecular Biology

Section discussions

Just published @PeerJLife study examines the long-term effects of non-biodegradable polyelectrolyte microcapsules on fish internal organs with histopathologic analysis Read the full article #Aquaculture #Fisheries #Biochemistry #Biotechnology

Research from Langenfeld et al. @UMich compares ultrafiltration and iron chloride flocculation in the preparation of aquatic viromes from contrasting sample types Read the full @PeerJLife article @envirophage #Microbiology #MolecularBiology #Virology

5 days ago
Analysis of Odonata #DNAbarcode library today in @thePeerJ #Entomology #MolecularBiology #Taxonomy #Zoology #FreshwaterBiology