Biochemistry, Biophysics and Molecular Biology

Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway
Paul Tulkens –– This paper shows that an aprenylflavonoid derivative from Epimedium brevicornum Maxim may have neuroprotective effects. Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits indeed the secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway. This effect, however, is only studied in vitro, calling for further studies demonstrating its potential in vivo.
Design and preliminary application of affinity peptide based on the structure of the porcine circovirus type II Capsid (PCV2 Cap)
Omar Gonzalez-Ortega –– Improvements in protein purification are always relevant. The in silico procedure followed is interesting.
Propofol inhibits stromatoxin-1-sensitive voltage-dependent K+ channels in pancreatic β-cells and enhances insulin secretion
Vladimir Uversky –– The manuscript reports important data and definitely will have a noticeable impact.
Transcriptome profiling analysis reveals key genes of different coat color in sheep skin
Cong-Jun Li –– The wool of sheep is a crucial product financially for farmers. Understanding the genetic regulation of wool color is very important as it can be the necessary information for the genetic selection of sheep breed
Magnetically directed antioxidant and antimicrobial agent: synthesis and surface functionalization of magnetite with quercetin
Eder Lenardao –– The combined properties of the new nanocomposite with quercetin makes it a promising candidate for application in biomedicine. It's the first report on the combination of the natural bioactive flavonoid quercetin with magnetite nanoparticles.
New sources of Sym2A allele in the pea (Pisum sativum L.) carry the unique variant of candidate LysM-RLK gene LykX
Yuriy Orlov –– The work presents additional pea lines with a Sym2A allele. It highlights ligand receptor compatibility determining rhizobial nodulation of legumes.
Characterization of aminopeptidase encoding gene anp-1 and its association with development in Caenorhabditis elegans
Juan Riesgo-Escovar –– I think this article will be important for people working on C. elegans development, at least.
Presence of Papillomavirus DNA sequences in the canine transmissible venereal tumor (CTVT)
Vladimir Uversky –– An important study showing that transmissible venereal tumor in dogs can be caused by Canine papillomavirus
Validation of COI metabarcoding primers for terrestrial arthropods
Xavier Pochon –– A very impressive work offering the most comprehensive validation of COI metabarcoding primers for terrestrial arthropods to date.
Expression of leptin and leptin receptors in colorectal cancer—an immunohistochemical study
Sarwat Naz –– The findings are clinically relevant in understanding the role of leptin and leptin receptors in the pathphysiology of colon cancer and its correlation with obesity /tumor metabolism.
Biochemistry, Biophysics and Molecular Biology
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Azev et al. @USouthFlorida - Chemical synthesis of peptidoglycan mimetic–disaccharide-tetrapeptide conjugate and its hydrolysis by bacteriophage Read the full @PeerJLife article https://t.co/odZZzg7RXJ #Biochemistry #Biophysics #Biotechnology https://t.co/tGVapcNoIl

My article has been published today in @thePeerJ https://t.co/vjwtbwTqmB #Biochemistry #CellBiology #MolecularBiology

Just published in @PeerJLife - #SPMLMI: predicting lncRNA–miRNA interactions in humans using a structural perturbation method Read the full article https://t.co/kMXraoTuKj #Bioinformatics #ComputationalBiology #MolecularBiology https://t.co/Qn4Q7nBl4O

Liver proteome alterations in psychologically distressed rats and a nootropic drug https://t.co/psbxebYP9n @thePeerJ https://t.co/SnVEpwDrvO

Native to designed: microbial α-amylases for industrial applications https://t.co/Y6ga2iENeZ @thePeerJ https://t.co/hSjqhmLjNJ

High glucose treatment promotes extracellular matrix proteome remodeling in Müller glial cells - Research from Sagmeister et al. @LMU_Muenchen Read the full @PeerJLife article https://t.co/dwQ7GJt699 #CellBiology #MolecularBiology #Neuroscience https://t.co/RpW8I3PtWH

Description of three #NewSpecies of #Geometridae using species delimitation in an integrative taxonomy approach for a cryptic species complex Read the full @PeerJLife article https://t.co/jwFBlHeKqo @unicampoficial @usponline #Biodiversity #Entomology #Taxonomy https://t.co/yjMLhSEabN

An integrative monograph of Carex section Schoenoxiphium (Cyperaceae) https://t.co/rxXyvzSB54 by @TVillaverde_ @jimarcorr @MEscudero_Carex @pjimmej @S_Martin_Bravo and colleagues https://t.co/tGxOJVD67F