Biochemistry, Biophysics and Molecular Biology

Evaluation of the effective dose of amygdalin for the improvement of antioxidant gene expression and suppression of oxidative damage in mice
Sanket Joshi –– The administration of low-medium dose of amygdalin showed improved oxidative balance in male-mice models, and further-future studies and experiments might highlight it as a potential cancer therapy option (however few contrasting reports also showing potentially fatal cyanide poisoning)!
Expression and protease characterization of a conserved protein YgjD in Vibrio harveyi
Mohammed Gagaoua –– Interesting manuscript that characterized a protease from Vibrio harveyi
Application of High Resolution Melt analysis (HRM) for screening haplotype variation in a non-model plant genus: Cyclopia (Honeybush)
Gabriele Casazza –– Add new methodological information on genetic analyses
Luteolin attenuates doxorubicin-induced cardiotoxicity by modulating the PHLPP1/AKT/Bcl-2 signalling pathway
Cheng-Chia Yu –– Luteolin administration as novel and natural therapeutic to protect against chemotherapy-induced cardiotoxicity
The GAR domain integrates functions that are necessary for the proper localization of fibrillarin (FBL) inside eukaryotic cells
David Tollervey –– The repeat structure and presence of methylation in GAR / RGG domains is a conserved feature of many proteins, This work helps clarify their functional significance.
Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway
Jesús Campos-García –– Scientific knowledge about the mechanisms of action of natural products is relevant to understand their ancient use in the treatment of diseases. Deep in the molecular mechanisms involved is a scientific challenge.
A real-time PCR assay to accurately quantify polar bear DNA in fecal extracts
Xavier Pochon –– A valuable novel qPCR assay for accurate quantification of the amount of polar bear DNA in fecal extracts!
DeepBindPoc: a deep learning method to rank ligand binding pockets using molecular vector representation
Walter de Azevedo Jr. –– In this research paper, Zhang et al. report the development of a new computational tool to assess protein-ligand interaction using machine-learning techniques. This new approach can rank ligand-binding pockets using molecular vector representation. The predictive power of this new method has been determined using high-resolution crystallography structures of protein-ligand complexes. The authors demonstrated that their computational approach has a complementary advantage over the popular Fpocket score in many test cases.
Characterizing metabolic stress-induced phenotypes of Synechocystis PCC6803 with Raman spectroscopy
Siouxsie Wiles –– New tools to study bacterial response to stresses/environmental changes.
Icariin affects cell cycle progression and proliferation of human retinal pigment epithelial cells via enhancing expression of H19
Diego Wilke –– Natural products are a prolific source if medicines highly relevant to treat countless human diseases. In this paper, icaridin effects suitable to treat retinopathy is depicted.
Biochemistry, Biophysics and Molecular Biology

Section discussions

First body of evidence suggesting a role of a tankyrase-binding motif (TBM) of vinculin (VCL) in epithelial cells @thePeerJ

New article @PeerJLife #Biodiversity #Biogeography #MarineBiology #MolecularBiology

New insight into the divergent responses of plants to warming in the context of root endophytic bacterial and fungal communities Read the full @PeerJLife article #Ecology #Microbiology #Mycology #PlantScience

The #GRAS gene family in #watermelons: identification, characterization and expression analysis of different tissues and root-knot nematode infestations Read the full @PeerJLife article #Agriculture #Genomics #PlantScience #SoilScience

Identification and analysis of Chrysanthemum nankingense NAC transcription factors and an expression analysis of OsNAC7 subfamily members @thePeerJ

#Paracercion are common ‘blue and black’ colored #damselflies. @PeerJLife article explores the species boundaries of Paracercion using distance-based clustering Read the full article #Entomology #MolecularBiology #Taxonomy