Biochemistry, Biophysics and Molecular Biology

Crucial biological functions of CCL7 in cancer
Howard Young –– This is a valuable review on an important topic that is not often reviewed. Thus it will provide a better understanding of the state of the literature on this important chemokine pathway.
How well do force fields capture the strength of salt bridges in proteins?
Emanuele Paci –– The paper provides a test case for testing polarizable force fields for the simulations of proteins.
Pretreating mesenchymal stem cells with electrical stimulation causes sustained long-lasting pro-osteogenic effects
Eva Mezey –– MSCs have a central role in regenerative medicine as well as in immune-regulation. Thus any manipulation that affects the function of these cells is significant since it might alter their character and affect their use.
An improved primer set and amplification protocol with increased specificity and sensitivity targeting the Symbiodinium ITS2 region
Tomas Hrbek –– Optimized protocol for amplification of Symbiodinium ITS2 region, that makes great strides towards generating reproducible and comparable data across a diversity of studies.
Unfolding of α-helical 20-residue poly-glutamic acid analyzed by multiple runs of canonical molecular dynamics simulations
Freddie Salsbury Jr –– important model system that is well-characterized in this study
Characterization of antimicrobial resistance genes in Haemophilus parasuis isolated from pigs in China
Sheng Chen –– A detail characterization of antibiotic resistance in Haemophilus parasuis, which is a very important animal pathogen. No much research work has been done in this organism in particular in the area of antimicrobial resistance.
Interaction of a dinoflagellate neurotoxin with voltage-activated ion channels in a marine diatom
Susanne Menden-Deuer –– The work investigates the physiological basis of toxin targets that are widespread in animals and even phytoplankton.
Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study
Francois van der Westhuizen –– The key outcome of the study is the finding, using metabolomics in an in vitro model, to demonstrate the value of low intensity repetitive magnetic in the stimulation of neural tissue and that it modulates neuronal excitability. There is a strong element of novelty in this work and I believe it will be well cited.
PBxplore: a tool to analyze local protein structure and deformability with Protein Blocks
Walter de Azevedo Jr. –– The authors report the development and application of a suite of tools, called PBxplore. This computational tool can be used to analyze the dynamics and deformability of protein structures using Protein Blocks (PBs). It is an interesting development for scientists interesting in molecular dynamics simulations of protein structures.
Validation of picogram- and femtogram-input DNA libraries for microscale metagenomics
Hauke Smidt –– The method described here allows to probe the metagenomes of low-biomass ecosystems at significantly reduced bias.
Biochemistry, Biophysics and Molecular Biology

Section discussions

Wang et al. examine how barley grain size impacts storage capacity during grain filling with the use of molecular markers Read the full @PeerJLife article #AgriculturalScience #Genetics #MolecularBiology #PlantScience

Kim et al. @SNUnow reveal a new coral barnacle exclusively associated with the high latitude coral Alveopora japonica in the waters of southern Korea after DNA-based diversity assessment Read the full @PeerJLife article #Biodiversity #MarineBiology

Phenotypic, molecular and pathogenic characterization of Colletotrichum scovillei infecting Capsicum species in Rio de Janeiro, Brazil @thePeerJ

Comparative transcriptome and histological analyses provide insights into the skin pigmentation in Minxian black fur sheep (Ovis aries) @thePeerJ

Transcriptomics analysis reveals the effect of Broussonetia papyrifera L. fermented feed on meat quality traits in fattening lamb @thePeerJ

Artículo original de la LCF: Dysregulation of miR-381-3p and miR-23b-3p in skeletal muscle could be a possible estimator of early post-mortem interval in rats. Disponible en: