Biochemistry, Biophysics and Molecular Biology

Article commentary

Genes of the major histocompatibility complex highlight interactions of the innate and adaptive immune system

Editor rating: 7 / 10

Carlo Ennio Pucillo –– it is of interest to the people that work on the specific topic,
Influence of CNTRENE® C100LM carbon nanotube material on the growth and regulation of Escherichia coli

Editor rating: 8 / 10

Regina-Michaela Wittich –– The input of commercial materials.
RNA helicase domains of viral origin in proteins of insect retrotransposons: possible source for evolutionary advantages

Editor rating: 7 / 10

Yegor Vassetzky –– The MS describes the transfer of viral helicases to insect retrotransposons.
Occasional hybridization between a native and invasive Senecio species in Australia is unlikely to contribute to invasive success

Editor rating: 8 / 10

Curtis Daehler –– While numerous studies have pointed out threats posed by hybridization between native and invasive species, this work provides a counter-example: Although hybrids were detected, hybridization does not seem to pose a risk to the native species or promote spread of the invader.
A positive readout single transcript reporter for site-specific mRNA cleavage

Editor rating: 8 / 10

Erich Schwarz –– To my knowledge, this is the first reporter for miRNA activity that works without secondary gene products (proteins) that can, at best, work in a cumbersome and unreliable manner to generate readouts from miRNA action. This reporter has the potential to applied therepeutically to induce cell-specific gene activity (either of a toxin gene, or of some other desired gene) in only those cells that happen to be expressing a particular miRNA (such as onco-miRNAs). This reporter should be able to work in any cell type of any metazoan with functioning miRNAs. The reasoning that led to this work is clear, direct, and elegant. The minor technical imperfections, which the authors scrupulously report in their statistical analysis, may well be overcome by future optimization of the RNA hairpins used by the reporter (perhaps by in vitro evolution of the miRNA reporter itself).
DAPK1 as an independent prognostic marker in liver cancer

Editor rating: 7 / 10

Can Küçük –– DAPK1 expression level can be used as a prognostic biomarker in liver cancer which can potentially be used to choose better therapeutical option(s) based on its level.
Construction of a fur null mutant and RNA-sequencing provide deeper global understanding of the Aliivibrio salmonicida Fur regulon

Editor rating: 7 / 10

Rüdiger Ettrich –– I am convinced that the article indeed contributes to a deeper global understanding of the Aliivibrio salmonicida Fur regulon and reaches out to the adjacent disciplines. Thus the statement in the title is not overstated but indeed advertises the findings in this paper.
­Glial and stem cell expression of murine Fibroblast Growth Factor Receptor 1 in the embryonic and perinatal nervous system

Editor rating: 7 / 10

Maria Concetta Geloso –– The study adds useful information about the role of FGFR1 signaling during brain development.
Confluence does not affect the expression of miR-375 and its direct targets in rat and human insulin-secreting cell lines

Editor rating: 8 / 10

Padmapriya Banada –– this article addresses important issues in cell biology regarding the influence of high confluence on the expression of enriched miRNAs in beta cells. this is supported by additional studies which has also showed that confluency of cells can influence gene expression.
Phytochemical-rich medicinal plant extracts suppress bacterial antigens-induced inflammation in human tonsil epithelial cells

Editor rating: 7 / 10

Vincenzo Brancaleone –– The article is important beacuse of the role of phytochemical extracts in treatment of bacterial infection

Discussing these articles

I find report controversial, have to read more carefully though - [viral] RNA helicase in insect retrotransposons https://t.co/Lh6DIE97T8

Our article about about CNT toxicity in E.coli has been published in @thePeerJ! https://t.co/PQsXjCbu6C #Microbiology #Toxicology

My article has been published today in @thePeerJ https://t.co/JXDShBXzVo #MolecularBiology #PlantScience

A single-transcript reporter system for miRNA cleavage (and, my first article edited for PeerJ): https://t.co/iBSMmWDTjs