Biochemistry, Biophysics and Molecular Biology

Article commentary

Curcumin longa extract-loaded nanoemulsion improves the survival of endotoxemic mice by inhibiting nitric oxide-dependent HMGB1 release

Editor rating: 7 / 10

Jie Liu –– HMGB1 is an important target.
Lectins: an effective tool for screening of potential cancer biomarkers

Editor rating: 7 / 10

Sandhya Visweswariah –– A good review possibly the only one dealing in this area.
Effects of tire leachate on the invasive mosquito Aedes albopictus and the native congener Aedes triseriatus

Editor rating: 9 / 10

Ilaria Negri –– Aedes albopictus is an invasive mosquito species, able to adapt to many environments. This article helps to shed light on its ecology.
The jaw is a second-class lever in Pedetes capensis (Rodentia: Pedetidae)

Editor rating: 8 / 10

Robert Druzinsky –– This is a new approach to a long-standing problem in the biomechanics of rodent feeding.
Genes of the major histocompatibility complex highlight interactions of the innate and adaptive immune system

Editor rating: 7 / 10

Carlo Ennio Pucillo –– it is of interest to the people that work on the specific topic,
Influence of CNTRENE® C100LM carbon nanotube material on the growth and regulation of Escherichia coli

Editor rating: 8 / 10

Regina-Michaela Wittich –– The input of commercial materials.
RNA helicase domains of viral origin in proteins of insect retrotransposons: possible source for evolutionary advantages

Editor rating: 7 / 10

Yegor Vassetzky –– The MS describes the transfer of viral helicases to insect retrotransposons.
Occasional hybridization between a native and invasive Senecio species in Australia is unlikely to contribute to invasive success

Editor rating: 8 / 10

Curtis Daehler –– While numerous studies have pointed out threats posed by hybridization between native and invasive species, this work provides a counter-example: Although hybrids were detected, hybridization does not seem to pose a risk to the native species or promote spread of the invader.
A positive readout single transcript reporter for site-specific mRNA cleavage

Editor rating: 8 / 10

Erich Schwarz –– To my knowledge, this is the first reporter for miRNA activity that works without secondary gene products (proteins) that can, at best, work in a cumbersome and unreliable manner to generate readouts from miRNA action. This reporter has the potential to applied therepeutically to induce cell-specific gene activity (either of a toxin gene, or of some other desired gene) in only those cells that happen to be expressing a particular miRNA (such as onco-miRNAs). This reporter should be able to work in any cell type of any metazoan with functioning miRNAs. The reasoning that led to this work is clear, direct, and elegant. The minor technical imperfections, which the authors scrupulously report in their statistical analysis, may well be overcome by future optimization of the RNA hairpins used by the reporter (perhaps by in vitro evolution of the miRNA reporter itself).
DAPK1 as an independent prognostic marker in liver cancer

Editor rating: 7 / 10

Can Küçük –– DAPK1 expression level can be used as a prognostic biomarker in liver cancer which can potentially be used to choose better therapeutical option(s) based on its level.

Discussing these articles

I find report controversial, have to read more carefully though - [viral] RNA helicase in insect retrotransposons

A great article I helped peer review published today in @thePeerJ #Ecology #Entomology #Toxicology

511 days ago
The amazing jaw mechanics of the springhare: my new article published today in @thePeerJ #Zoology

Our article about about CNT toxicity in E.coli has been published in @thePeerJ! #Microbiology #Toxicology

My article has been published today in @thePeerJ #MolecularBiology #PlantScience

A single-transcript reporter system for miRNA cleavage (and, my first article edited for PeerJ):