Editor rating: 7 / 10Christopher Jolly –– Whether to not members of the APOBEC family of cytidine deaminases, which includes AID, dominate RNA or DNA or both has been a hotly debated topic since the publication of AID's role in antibody maturation in 2000. The overwhelming evidence in favour of Neuberger's DNA deamination model that emerged from 2001 onwards has produced the paradigm that APOBECs and AID perform their biological function by deaminating DNA. Nonetheless, this paper follows up earlier studies by the same authors that have demonstrated RNA-editing functions for APOBEC3A by demonstrating that substrate specificity for RNA-editing by APOBEC3A and G is dictated by RNA secondary structure, and not by the primary sequence flanking deamination sites. A bona fide RNA-editing function for APOBECs has major implications for their roles in cancer; it seems likely that mammalian cytidine deaminases will continue to surprise us for some time to come.
Editor rating: 8 / 10Patrizia Lavia –– The issue of how mitotic microtubules interact with the kinetochores of chromosomes is highly relevant to chromosome segregation, and hence to the generation of genetically balanced cells. Errors in the process are, on the contrary, detrimental to genetic stability. Microtubules, though being stably attached to chromosomes, must retain their dynamic ability throughout mitosis in order to move and pull the chromosomes towards the poles. MCAK is a kinesin that has an important role, is absolutely required in the process, yet its mechanism of action is known only in part. Here the authors expand our mechanistic understanding of this kinesin and propose an interesting model for its function. Their revised version is well written and has a very clear, convincing discussion that an reach a broad audience in the field of control of chromosome segregation and genome stability.
Editor rating: 9 / 10Walter de Azevedo Jr. –– The authors report the development and application of a suite of tools, called PBxplore. This computational tool can be used to analyze the dynamics and deformability of protein structures using Protein Blocks (PBs). It is an interesting development for scientists interesting in molecular dynamics simulations of protein structures.
Editor rating: 7 / 10Fabiano Thompson –– addresses virus diversity in reef systems, and roles in genome plasticity.
Editor rating: 7 / 10Barbara Nowak –– climate change will affect fish farming, this manuscript describes potential intervention and broodstock management for Atlantic salmon
Editor rating: 7 / 10Shao-Chen Sun –– This work focused on lncRNA, which is an active area currently.
Editor rating: 7 / 10Christopher Cooper –– One of very few articles on Trichoplax, an emerging model organism of increasing importance in evo-devo biology.
Editor rating: 7 / 10Jie Liu –– HMGB1 is an important target.
Editor rating: 7 / 10Sandhya Visweswariah –– A good review possibly the only one dealing in this area.
Editor rating: 9 / 10Ilaria Negri –– Aedes albopictus is an invasive mosquito species, able to adapt to many environments. This article helps to shed light on its ecology.
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